Introduction to Protein Crystallography-Inside of a Black Box-(2) Background of Phase Determination: Molecular Replacement Method

Accession number;06A0976103
Title;Introduction to Protein Crystallography-Inside of a Black Box-(2) Background of Phase Determination: Molecular Replacement Method
Author; TAKENAKA AKIO (Tokyo Inst. Technol, Graduate School of Bioscience and Biotechnology, JPN)
Journal Title;Journal of the Crystallographic Society of Japan
Journal Code:G0232A
ISSN:0369-4585
VOL.48;NO.5;PAGE.311-319(2006)
Figure&Table&Reference;FIG.14, REF.4
Pub. Country;Japan
Language;Japanese
Abstract;As an easy technique for phase determination in X-ray analysis of macromolecular crystals, the molecular replacement method is widely used. Available computer programs are highly sophisticated to user friendly so that users can use them without knowledge on the theoretical backgrounds. To develop the technique to more powerful tool, as well as to resolve individual problems in special cases, it is essential to understand the details of the backgrounds. Here the theories of the method with the historical backgrounds, its availability and capability, practical usage and trouble shooting will be described. (author abst.)