Tissue Array Analysis of the Aberrant Expression of HLA Class I Molecules in Human Non-Small Cell Lung Cancer
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Accession number;06A1011510
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| Title;Tissue Array Analysis of the Aberrant Expression of HLA Class I Molecules in Human Non-Small Cell Lung Cancer |
| Author;
SUZUKI HIROYUKI
(Fukushima Medical Univ., School of Medicine, JPN)
HIGUCHI MITSUNORI
(Fukushima Medical Univ., School of Medicine, JPN)
HASEGAWA TAKEO
(Fukushima Medical Univ., School of Medicine, JPN)
YONECHI ATSUSHI
(Fukushima Medical Univ., School of Medicine, JPN)
OSUGI JUN
(Fukushima Medical Univ., School of Medicine, JPN)
YAMADA FUMIHIKO
(Fukushima Medical Univ., School of Medicine, JPN)
HOSHINO MIKA
(Fukushima Medical Univ., School of Medicine, JPN)
SHIO YUTAKA
(Fukushima Medical Univ., School of Medicine, JPN)
FUJIU KOICHI
(Fukushima Medical Univ., School of Medicine, JPN)
GOTO MITSUKAZU
(Fukushima Medical Univ., School of Medicine, JPN)
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Journal Title;Japanese Journal of Cancer and Chemotherapy
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Journal Code:Z0938A
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ISSN:0385-0684
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VOL.33;NO.12;PAGE.1713-1716(2006)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A clinical significance of the aberrant expression of HLA class I molecules including HLA class I and HLA-G was analyzed using tissue array analysis. Our institute has established a two-millimeter spot sized tissue array set of 105 clinical cases of resected human non-small cell lung cancer tissues. A loss of HLA class I was observed in the 58.3% of cancer tissues. The aberrant expression of HLA-G was also observed in the 55.2% of cancer tissues. Statistically significant correlations were observed among HLA class I expression and tumor size, nodal involvement and pathological stage. Survival analyses were shown that the HLA class I loss was correlated to a recurrence free survival time. The HLA-G expression did not correlate with any clinico-pathological parameters. A loss of HLA class I was probably involved due to a cancer progression in human non-small cell lung cancer through the mechanism of immune escape from the host immune system. (author abst.) |
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