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Accession number;06A1040530
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| Title;Eosinophil and Atopic Dermatitis |
| Author;
TERUI TADASHI
(Nihon Univ.)
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Journal Title;Skin Research
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Journal Code:Z0014C
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ISSN:1347-1813
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VOL.5;NO.Suppl.7;PAGE.17-20(2006)
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| Figure&Table&Reference;REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In spite of the progress in the immunological study of atopic dermatitis (AD), the pathogenesis of this disease still remains unclear. Eosinophil number in the lesional skin and peropheral blood are elevated in most AD patients. Moreover, eosinophil granule proteins are deposited in the AD lesions. These observations suggest a pivotal role of eosinophils in the pathogenesis of AD. Furthermore, AD is associated with increased production of a T helper 2 cytokine, interleukin (IL)-5, which specifically acts on production, activation, and life-prolongation of eosinophils. Based on these observations, eosinophils appear to be interesting targets for therapy in AD. (author abst.) |
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