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Accession number;06A1040541
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| Title;A Possible Gene Therapy by STAT6 Decoy ODN Ointment for Atopic Dermatitis |
| Author;
YOKOZEKI HIROO
(Tokyo Med. and Dent. Univ.)
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Journal Title;Skin Research
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Journal Code:Z0014C
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ISSN:1347-1813
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VOL.5;NO.Suppl.7;PAGE.57-61(2006)
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| Figure&Table&Reference;FIG.6, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;There are currently no effective therapies for severe atopic dermatitis except for the administration of glucocorticoids or immunosuppressants which have several severe side effects. The transfection of cis-element double-stranded oligodeoxynucleotides (ODNs), reffered to as "decoy", has been reported to be a powerful tool and a new type antigene treatment strategeis for gene therapy and for study gene transfection. Systemic ODNs act as decoy cis-elements to block the binding of nuclear factors to the promoter regions of targeted genes, thus resulting in the inhibition of gene transactivation both in vitro and in vivo. Recently, a targeted disruption of the STAT6 DNA binding activity by a STAT6 decoy has been reported to block IL-4-deriven Th2 cell response in vitro, and reported the inhibitory effect of a STAT6 Decoy ODN on the induction of the IgE medicated late phase reaction in AD mouse model in vivo system, acute and chronic contact hypersensitivity and TNP-IgE-transgenic mice. In this paper, we demonstrated that STAT6 decoy ODN ointment can be effective for patients with AD as a gene therapy in a clinical study. (author abst.) |
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