Amlodipine, a Calcium Channel Blocker, Dilates Glomerular Efferent Arterioles by N-type Calcium Channel Blockade
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Accession number;07A0026933
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| Title;Amlodipine, a Calcium Channel Blocker, Dilates Glomerular Efferent Arterioles by N-type Calcium Channel Blockade |
| Author;
KONNO YUSUKE
(St. Marianna Univ. School of Medicine, JPN)
KIMURA KENJIRO
(St. Marianna Univ. School of Medicine, JPN)
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Journal Title;Ther Res
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Journal Code:Y0681A
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ISSN:0289-8020
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VOL.27;NO.11;PAGE.2113-2118(2006)
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| Figure&Table&Reference;FIG.3, REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The objective of this study was to investigate the mechanism by which the calcium channel blocker amlodipine elicits vasodilation of glomerular efferent arterioles in hypertensive rats. Hydronephrosis was induced by permanent ligation of the left ureter in 8-week-old spontaneously hypertensive rats. After the hydronephrotic left kidney was split longitudinally and spread out as a thin sheet, the renal microvasculature was observed directly under a light microscope. Administration of amlodipine 200.MU.g/kg caused a gradual fall in systolic blood pressure (20-30 mmHg). Both the afferent and efferent arterioles were dilated 30% and 32% at 20 minutes, respectively. Pre-treatment with .OMEGA.-conotoxin led to a weakening of the amlodipine-induced vasodilatory effect on afferent arterioles, and elimination of the vasodilatory effect on efferent arterioles. Amlodipine exerts effects on the renal microvasculature, and N-type calcium channel blockade appears to be implicated in its vasodilatory effect on the efferent arterioles. (author abst.) |
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