Science Links Japan | Beneficial Effects of Zinc Supplementation for the Treatment of NAFLD

Beneficial Effects of Zinc Supplementation for the Treatment of NAFLD

Accession number;07A0026934

Title;Beneficial Effects of Zinc Supplementation for the Treatment of NAFLD

Author; TAKAMATSU SEIGO (Kishiwada Tokushukai Hosp.) HIROOKA TOMOOMI (Kishiwada Tokushukai Hosp.) UEDA CHIE (Kishiwada Tokushukai Hosp.) SHINJO ISATO (Kishiwada Tokushukai Hosp.) IWATA YOSHINORI (Kishiwada Tokushukai Hosp.) ONO WATARU (Kishiwada Tokushukai Hosp.) SUGIYAMA RIEKO (Kishiwada Tokushukai Hosp.) SUGIYAMA KEN (Kishiwada Tokushukai Hosp.) TOYONAGA TAKASHI (Kishiwada Tokushukai Hosp.) DOSAIKU TOSHIO (Kishiwada Tokushukai Hosp.) HIROOKA TAKASHI (Kishiwada Tokushukai Hosp.)

Journal Title;Ther Res

Journal Code:Y0681A

ISSN:0289-8020

VOL.27;NO.11;PAGE.2119-2125(2006)

Figure&Table&Reference;FIG.6, TBL.2, REF.9

Pub. Country;Japan

Language;Japanese

Abstract;Background: Non-alcoholic steatohepatitis (NASH) is a disease characterized by histological features of liver fibrosis together with steatosis and lobular inflamation. The disease is onset mainly in obesity, often associated with diabetes mellitus and hyperlipidemia. Recently, we reported that zinc supplementation regress liver fibrosis in patients with chronic hepatitis B/C virus infection. Objectives: The aims of this study were to investigate the efficacy of zinc supplementation for the progression of liver fibrosis in patients with NAFLD (non-alcoholic fatty liver disease) including NASH. Methods: Fourteen patients of NAFLD, including 1 patients of histological diagnosis of NASH, and 13 patients of clinical diagnosis correspond to NASH were enrolled, and then were orally administrated ursodeoxycholic acid, bezafibrate and polaprezinc (zinc-containing drug) for 6 months. Results: After 6 months of treatment, ALT and type IV-collagen-7S levels were significantly decreased in patients with an elevated serum zinc levels (more than mean+2 SD at base line), but no significant changes in patients with an unchanged serum zinc levels. On the other hand, a decreased BMI (body mass index) had little beneficial effect in this study. Conclusions: These results suggest that zinc supplementation is particularly beneficial for the restoration of liver function and the regression of liver fibrosis in patients with NAFLD. (author abst.)

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