Mechanisms of Acute Sensitization and Development of Irritable Bowel Syndrome: An Acute Sensitization by Order of Visceral Stimulation
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Accession number;07A0044255
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| Title;Mechanisms of Acute Sensitization and Development of Irritable Bowel Syndrome: An Acute Sensitization by Order of Visceral Stimulation |
| Author;
HAMAGUCHI TOYOHIRO
(Tohoku Univ., Graduate School of Medicine, JPN)
HAMAGUCHI TOYOHIRO
(Niigata Univ. Health and Welfare, School of Health Sci., JPN)
KANAZAWA MOTOYORI
(Tohoku Univ., Graduate School of Medicine, JPN)
FUKUDO SHIN
(Tohoku Univ., Graduate School of Medicine, JPN)
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Journal Title;Japanese Journal of Psychosomatic Medicine
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Journal Code:Z0162B
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ISSN:0385-0307
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VOL.47;NO.1;PAGE.19-24(2007)
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| Figure&Table&Reference;FIG.3, REF.25 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Several features of irritable bowel syndrome (IBS) suggest involvement of the emotional limbic system in the brain. Abnormalities which upregulate afferent signal intensity anywhere in this system, from the gastrointestinal tract to the brain, could induce hypersensitivity, leading to the pain and discomfort in IBS. Functional gastrointestinal disorders are likely to be heterogeneous given the complexity of the afferent system, and a number of different perturbations are possible. Intestinal hypersensitivity to pain and discomfort might explain the symptoms of functional bowel diseases. Recent breakthroughs in the neurophysiology of visceral perception and emotion are providing a series of plausible mechanisms to explain the development of hyperalgesia within the human gastrointestinal tract. Taking clinical characteristics and the concept of central sensitization into account, a model is proposed by which visceral perception and emotion from colonic distention and stimulus conditioning. (author abst.) |
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