Polymorphisms of the Factor VII Gene Associated with the Low Activities of Vitamin K-Dependent Coagulation Factors in One-Month-Old Infants
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Accession number;07A0040435
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| Title;Polymorphisms of the Factor VII Gene Associated with the Low Activities of Vitamin K-Dependent Coagulation Factors in One-Month-Old Infants |
| Author;
ITO KOICHI
(Dep. of Pediatrics, Neonatology and Congenital Disorders, Nagoya City Univ., Graduate School of ...)
GOTO KENJI
(Dep. of Pediatrics, Neonatology and Congenital Disorders, Nagoya City Univ., Graduate School of ...)
SUGIURA TOKIO
(Department of Pediatrics, Toyohashi Municipal Hospital)
MURAMATSU KANJI
(Department of Pediatrics, Nagoya Daini Red Cross Hospital)
ANDO TOSHIHIRO
(Nishimikawa Child and Disabled Person Guidance Center)
MANIWA HIROKO
(Department of Pediatrics, Nishio Municipal Hospital)
YOKOYAMA TAKAO
(Department of Pediatrics, Nishio Municipal Hospital)
SUGIYAMA KOHACHIRO
(Sugiyama Children's Clinic)
TOGARI HAJIME
(Dep. of Pediatrics, Neonatology and Congenital Disorders, Nagoya City Univ., Graduate School of ...)
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Journal Title;Tohoku J Exp Med
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Journal Code:G0649A
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ISSN:0040-8727
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VOL.211;NO.1;PAGE.1-8 (J-STAGE)(2007)
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| Figure&Table&Reference;FIG.1, TBL.3, REF.17 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Despite administration of vitamin K (VK), some infants show lower activity of VK-dependent coagulation factors and they could develop intracranial hemorrhage. For preventing VK deficiency bleeding (VKDB) in infants, oral administration of VK and a screening test for VK deficiency are carried out in Japan. For the screening, the total activity of VK-dependent coagulation factors is measured using a commercial product, Normotest''. This study was undertaken to clarify the importance of the following genetic and environmental factors on the coagulation status in one-month-old infants: two polymorphisms in the factor VII gene, -323P0/10 (a 10-bp insertion in the promoter region at position -323) and R353Q (the replacement of arginine [R] with glutamine [Q] at residue 353) and sex, age, gestational age, birth weight, and feeding regimen. Two hundred Japanese infants (34.6 .+-. 4.0 days old) were screened for VK-dependent coagulation activity with Normotest and were genotyped for the two polymorphisms. Among the subjects screened, 18 infants (9%) carried the P10 allele and 26 (13%) carried the R353Q allele. Multiple regression analysis showed that the 10-bp inserted (P10) allele or the Q allele was associated with the lower coagulation activities. The coagulation activities for the R/Q genotype were significantly lower than those for the R/R genotype and those for the P0/P10 genotype were significantly lower than those for the P0/P0 genotype. Therefore, infants who carry the P10 allele or the Q allele show lower activity of VK-dependent coagulation factors. These infants may have a higher risk of VKDB manifestation. (Author abst.) |
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