Strain-Specific Pulmonary Defense Achieved after Repeated Airway Immunizations with Non-Typeable Haemophilus Influenzae in a Mouse Model
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Accession number;07A0040442
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| Title;Strain-Specific Pulmonary Defense Achieved after Repeated Airway Immunizations with Non-Typeable Haemophilus Influenzae in a Mouse Model |
| Author;
KOYAMA JUN
(Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University)
AHMED KAMRUDDIN
(Div. of Infectious Diseases, Dep. of Social and Environmental Medicine, Inst. of Scientific ...)
ZHAO JIZI
(Dep. of Special Pathogen, International Res. Center for Infectious Diseases, Res. Inst. for ...)
SAITO MARIKO
(Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University)
ONIZUKA SHOZABURO
(Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University)
OMA KEITA
(Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University)
WATANABE KIWAO
(Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University)
WATANABE HIROSHI
(Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University)
OISHI KAZUNORI
(Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University)
OISHI KAZUNORI
(Dep. of Special Pathogen, International Res. Center for Infectious Diseases, Res. Inst. for ...)
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Journal Title;Tohoku J Exp Med
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Journal Code:G0649A
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ISSN:0040-8727
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VOL.211;NO.1;PAGE.63-74 (J-STAGE)(2007)
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| Figure&Table&Reference;FIG.4, TBL.4, REF.30 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Strain-specific immune responses may play a critical role in the acute exacerbation of chronic obstructive pulmonary disease (COPD) caused by Haemophilus influenzae (NTHi), and the outer membrane protein P2 is one of surface antigens of NTHi, which may contribute to the strain-specific protective immunity. We examined whether repeated airway immunizations with killed-NTHi strains bearing different P2 molecules were capable of inducing protective immunity against homologous or heterologous strains in the lungs of a mouse model. Three different strains of NTHi were used in this study. Three serial intratracheal (IT) immuizations of a single strain or three different strains of NTHi led to the production of cross-reactive immunoglobulins G and A in bronchoalveolar lavage fluids. Three serial IT immunizations with a single strain enhanced the bacterial clearance of the homologous strain in the lungs, but no enhancement of bacterial clearance was found with three serial IT immunizations of heterologous strains. The enhancement in bacterial clearance, therefore, appears to be primarily strain-specific. Enhanced bacterial clearance of a hetrologous strain was also found after three serial IT immunizations of a single strain among two of the three strains employed for bacterial challenge. These findings suggest that P2 molecules and surface antigens other than P2 are involved in the development of pulmonary defense against NTHi in mice. Our data may explain, in part, why patients with COPD experience recurrent NTHi infections. (Author abst.) |
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