Cholesterol-Years Score is Associated with Development of Senile Degenerative Aortic Stenosis in Heterozygous Familial Hypercholesterolemia
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Accession number;07A0040472
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| Title;Cholesterol-Years Score is Associated with Development of Senile Degenerative Aortic Stenosis in Heterozygous Familial Hypercholesterolemia |
| Author;
NOZUE TSUYOSHI
(Molecular Genetics of Cardiovascular Disorders, Div. of Cardiovascular Medicine, Graduate School ...)
KAWASHIRI MASA-AKI
(Molecular Genetics of Cardiovascular Disorders, Div. of Cardiovascular Medicine, Graduate School ...)
HIGASHIKATA TOSHINORI
(Molecular Genetics of Cardiovascular Disorders, Div. of Cardiovascular Medicine, Graduate School ...)
NOHARA ATSUSHI
(Department of Lipidology, Graduate School of Medical Science, Kanazawa University.)
INAZU AKIHIRO
(Department of Health Science, Kanazawa University.)
KOBAYASHI JUNJI
(Department of Lifestyle-related Disease, Graduate School of Medical Science, Kanazawa University.)
KOIZUMI JUNJI
(Department of General Medicine, Kanazawa University Hospital.)
YAMAGISHI MASAKAZU
(Molecular Genetics of Cardiovascular Disorders, Div. of Cardiovascular Medicine, Graduate School ...)
MABUCHI HIROSHI
(Department of Lipidology, Graduate School of Medical Science, Kanazawa University.)
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Journal Title;J Atheroscler Thromb
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Journal Code:L2187A
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ISSN:1340-3478
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VOL.13;NO.6;PAGE.323-328 (J-STAGE)(2006)
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| Figure&Table&Reference;TBL.5, REF.33 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We retrospectively evaluated the frequency and identified the factors associated with the development of aortic stenosis (AS) in 96 patients with heterozygous familial hypercholesterolemia (FH). The frequency of AS was 31% (4/13) and that of critical stenosis was 15% (2/13) in older patients over the age of 70 years. All 4 patients with AS were female aged more than 70 years who were diagnosed with FH when aged more than 60 years. There were no significant differences in conventional coronary risk factors; however, the age at cardiac catheterization, age at diagnosis of FH and the cholesterol-years score (CYS) with AS were significantly higher than those without AS (p=0.006, p=0.017, p=0.021, respectively). In multiple regression analysis, CYS was a significant independent predictor for the development of AS (p=0.037) in 13 older patients over the age of 70 years. These results suggest that physicians should be aware that AS needs attention in older patients with heterozygous FH, especially women who have been diagnosed late in life and those who have been inadequately treated. (Author abst.) |
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