Action mechanisms of .ALPHA.-hydroxy acids such as glycolic acid on photaged skin
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Accession number;07A0095809
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| Title;Action mechanisms of .ALPHA.-hydroxy acids such as glycolic acid on photaged skin |
| Author;
SUEKI HIROHIKO
(Showa Univ., Fujigaoka Hospital, JPN)
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Journal Title;Aesthetic Dermatol
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Journal Code:L5200A
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ISSN:1341-5530
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VOL.16;NO.4;PAGE.281-286(2006)
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| Figure&Table&Reference;FIG.6, TBL.1, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Dermatologists who are aware of the action mechanisms of .ALPHA.-hydroxy acids (AHA) such as glycolic acid should perform chemical peeling. Herein our data and recent advances in the effects of AHA on photoaged skin are reviewed. The principal actions of AHA on the epidermis include accelerated detachment of corneal layers, acanthosis, opening of the intercellular space, and increased density of anchoring fibrils. As for the dermis, increased amounts of acid muco-polysaccharides, a higher level of mast cell degranulation, and increased factor XIIIa expression on dermal dendrocytes were observed, suggesting that matrix repair was in progress. Although data showing increased collagen synthesis by the application of AHA have been reported, the increased density of collagen fibers in our study was not significant. (author abst.) |
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