Decreased magnesium in whole blood of patients with porphyria cutanea tarda
|
Accession number;07A0075790
|
| Title;Decreased magnesium in whole blood of patients with porphyria cutanea tarda |
| Author;
KONDO MASAO
(National Inst. Health And Nutrition, Tokyo, Jpn)
MIYAMOTO HIROSHI
(Chiba City Inst. Health And Environment, Chiba, Jpn)
CHOUNOU TARO
(Chiba City Inst. Health And Environment, Chiba, Jpn)
HORIE YUTAKA
(Saiseikai Gotsu General Hospital, Shimane, Jpn)
URATA GUMPEI
(National Inst. Health And Nutrition, Tokyo, Jpn)
|
Journal Title;Porphyrins
|
Journal Code:L2180A
|
ISSN:0918-4368
|
|
VOL.15;NO.2/3;PAGE.51-56(2006)
|
| Figure&Table&Reference;FIG.4, TBL.1, REF.12 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Sporadic porphyria cutanea tarda (PCT) is a metabolic disorder of heme biosynthesis that presents in adults and is associated with cutaneous lesions characterized clinically by mechanical fragility and blistering of light-exposed skin and biochemically by uroporphyrinuria. Liver disease is almost always present in PCT and mild to moderate iron overload is common. Iron is one of the factors that trigger the clinical manifestations of the disease, contributing to the inactivation of uroporphyrinogen decarboxylase (UROD). We investigated various elements in the peripheral blood of 5 patients (mean age 51.4 years old) with this disease and 5 normal healthy controls. Concentrations of 23 elements (Al, As, Ba, Ca, Cd, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Mo, Ni, Pb, Rb, Se, Sn, Sr, Ti, V, Zn) were determined using an inductively couple plasma mass spectrometer (ICP-MS) or an inductively couple plasma atomic emission spectrometer (ICP-AES). As a result, Mg, Ni, Se (p<0.05) and Rb (p<0.01) concentrations in whole blood were decreased significantly, whereas Mo was significantly increased in PCT patients compared to control values (p<0.01). The results suggest that fluctuation of these elements contributes to the cause of PCT. (author abst.) |
|
|
|
Related Articles;
|
|
