Analysis of CheA-CheYp Affinity and Adaptation Error in Bacterial Chemotaxis
|
Accession number;07A0176816
|
| Title;Analysis of CheA-CheYp Affinity and Adaptation Error in Bacterial Chemotaxis |
| Author;
MATSUZAKI YURI
(Inst. Advanced Biosciences, Keio Univ., JPN)
MATSUZAKI YURI
(Keio Univ., Graduate School of Media and Governance, JPN)
KIKUCHI SHIN'ICHI
(Inst. Advanced Biosciences, Keio Univ., JPN)
KIKUCHI SHIN'ICHI
(Keio Univ., Faculty of Enviromental Information, JPN)
TOMITA MASARU
(Inst. Advanced Biosciences, Keio Univ., JPN)
TOMITA MASARU
(Keio Univ., Faculty of Enviromental Information, JPN)
|
Journal Title;IPSJ Transactions on Database
|
Journal Code:Z0778A
|
ISSN:0387-5806
|
|
VOL.48;NO.SIG2(TOM16);PAGE.91-97(2007)
|
| Figure&Table&Reference;FIG.3, TBL.6, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The chemotaxis system in Escherichia coli consists of a series of signal transduction pathways which respond to changes in the environment. As one of the most extensively studied signaling mechanism, the molecular structure of the chemotaxis pathway has been well characterized, enabling a number of analyses and model studies. Two key elements of the chemotaxis pathway include the amplification of signals from attractants and the accuracy of adaptation. Recent simulation studies using models incorporating receptor crosstalking, or the coupling effects of receptor activity and crosstalk of signaling molecules among different chemoreceptors, have suggested possible mechanisms for signal amplification. However, the adaptation behavior of these models has yet to be analyzed. In this study, we concentrated on how receptor crosstalk affects adaptation stability and error minimization of the system. By decreasing the affinity of CheA and phosphorylated CheY, we found that the model can adapt to attractant concentrations ranging from 0.1.MU.M to 10 mM with a decreased error rate from 8% to 2%. (author abst.) |
|
|
|
Related Articles;
|
|
