Effects of .ALPHA.-linolenic acid on colonic secretion in rats with experimental colitis
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Accession number;07A0256501
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| Title;Effects of .ALPHA.-linolenic acid on colonic secretion in rats with experimental colitis |
| Author;
SHIMIZU TOSHIAKI
(Juntendo Univ. School Of Medicine, Tokyo, Jpn)
KITAMURA TOMOHIRO
(Juntendo Univ. School Of Medicine, Tokyo, Jpn)
SUZUKI MITSUYOSHI
(Juntendo Univ. School Of Medicine, Tokyo, Jpn)
FUJII TOHRU
(Juntendo Univ. School Of Medicine, Tokyo, Jpn)
SHOJI HIROMICH
(Juntendo Univ. School Of Medicine, Tokyo, Jpn)
TANAKA KYOKO
(Juntendo Univ. School Of Medicine, Tokyo, Jpn)
IGARASHI JUN
(Juntendo Univ. School Of Medicine, Tokyo, Jpn)
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Journal Title;J Gastroenterol
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Journal Code:Z0748A
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ISSN:0944-1174
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VOL.42;NO.2;PAGE.129-134(2007)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background. Few studies have specifically examined the effects of n-3 polyunsaturated fatty acids (PUFAs) on intestinal water and ion secretion in ulcerative colitis (UC). The aim of this study was to examine the contribution of prostaglandins (PGs) and leukotrienes (LTs) to mucosal secretion in intestines with UC and to evaluate the effect of dietary n-3 PUFAs on diarrhea in UC. Methods. We measured the short-circuit current (Isc), using the Ussing chamber method, and fatty acid composition in the colonic mucosa of rats with dextran sulfate sodium (DSS)-induced experimental colitis. The DSS-treated rats were fed either a perilla oil-enriched diet (perilla group) or a soybean oil-enriched diet (soybean group); a control group did not undergo DSS administration. Results. The bradykinin-stimulated .DELTA.Isc in the soybean and perilla groups was significantly higher than that in the control group. The mucosal level of arachidonic acid in the perilla group was significantly lower than that in the soybean group. The mucosal levels of .ALPHA.-linolenic acid and EPA in the perilla group were significantly higher than those in the soybean group. The bradykinin-stimulated .DELTA.Isc was significantly suppressed after pretreatment with indomethacin in both the soybean and perilla groups, and was also significantly reduced in both groups after pretreatment with AA861. The suppression of bradykinin-stimulated .DELTA.Isc by the addition of AA861 was significantly higher in the perilla group than in the soybean group. Conclusions. Our results suggest that supplementation with .ALPHA.-linolenic acid, in combination with a lipoxygenase inhibitor, could suppress the increase in Cl- secretion in patients with UC. (author abst.) |
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