A male patient with severe acute hepatitis who was domestically infected with a genotype H hepatitis B virus in Iwate, Japan

Accession number;07A0256507
Title;A male patient with severe acute hepatitis who was domestically infected with a genotype H hepatitis B virus in Iwate, Japan
Author; KUMAGAI ICHIRO (Iwate Medical Univ., Iwate, Jpn) ABE KOICHI (Iwate Medical Univ., Iwate, Jpn) OIKAWA TAKAYOSHI (Iwate Medical Univ., Iwate, Jpn) SATO AKIHIRO (Iwate Medical Univ., Iwate, Jpn) SATO SHINICHIRO (Iwate Medical Univ., Iwate, Jpn) ENDO RYUJIN (Iwate Medical Univ., Iwate, Jpn) TAKIKAWA YASUHIRO (Iwate Medical Univ., Iwate, Jpn) SUZUKI KAZUYUKI (Iwate Medical Univ., Iwate, Jpn) MASUDA TOMOYUKI (Iwate Medical Univ., Iwate, Jpn) SAINOKAMI SHIGEHIKO (Iwate Medical Univ., Iwate, Jpn) SAINOKAMI SHIGEHIKO (Oshu City Hospital, Iwate, Jpn) ENDO KAZUNORI (Jichi Medical Univ. School Of Medicine, Tochigi, Jpn) TAKAHASHI MASAHARU (Jichi Medical Univ. School Of Medicine, Tochigi, Jpn) OKAMOTO HIROAKI (Jichi Medical Univ. School Of Medicine, Tochigi, Jpn)
Journal Title;J Gastroenterol
Journal Code:Z0748A
ISSN:0944-1174
VOL.42;NO.2;PAGE.168-175(2007)
Figure&Table&Reference;
Pub. Country;Japan
Language;English
Abstract;Although all eight genotypes of hepatitis B virus (HBV) strains are circulating in Japan, no cases of acute hepatitis with foreign HBV strains of genotype H have thus far been reported in Japan. Here, we report a 35-year-old Japanese patient with severe acute hepatitis who was domestically infected with genotype H HBV. On admission, he had a high HBV load of 1.0*10'9' copies/ml, elevated levels of total bilirubin (7.0 mg/dl) and alanine aminotransferase (3606 IU/l), and reduced prothrombin activity of 39.0%. The HB-JAIW05 isolate obtained in the present study was composed of 3215 nucleotides and had the highest similarity of 99.7% with the reported genotype H HBV isolate recovered from a Japanese blood donor. The HB-JAIW05 isolate had neither precore (A1896) nor core promoter (T1762/A1764) mutations. However, upon comparison with the consensus sequence of ten reported HBV isolates of the same genotype, the HB-JAIW05 isolate had 17 nucleotide substitutions including five missense mutations in the P gene, which may be related to vigorous replication of HBV in this case. He had no history of traveling abroad, but had had extramarital sexual contact with two Japanese women living in Iwate, Japan, 2 weeks and 2 months before the disease onset, respectively. Our results suggest that rare HBV genotypes such as H may be spreading in Japan via sexual contact. Further molecular epidemiological studies on HBV to clarify the exact changing profiles of de novo HBV infection in Japan in relation to genotype and genomic variability are warranted. (author abst.)
Related Articles;
Loading...
FULLTEXT