Science Links Japan | Gan Kenkyu ni kakawaru Tokutei Ryoiki Kenkyu Kenkyu Hokoku Shuroku Heisei 15 Nendo (CD-ROM)

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Gan Kenkyu ni kakawaru Tokutei Ryoiki Kenkyu Kenkyu Hokoku Shuroku Heisei 15 Nendo (CD-ROM)

Research on EB virus and development of gastric cancer.
Analysis of onset mechanism of gastric cancer initiated by Helicobacter Pylori bacterial infection.
Mechanism of Igf2LOI in hepatoma cells of clone mouse.
Analysis of inhibition of gene expression by DNA methylation in gastrointestinal cancer.
Analysis of mutant genes with chromosomal aberration using model organisms.
Cell canceration ability of a chromatin-remodeling factor and nucleoporin fused oncogene.
Active domain of homologous recombination in tumor-suppressing DNA repair protein.
Molecular control mechanism and carcinogenesis of p53 by stability of p73 and delta Np73.
Carcinogenesis of liver cancer by hepatitis C virus.
Analysis of molecular mechanism of translocation leukemia by using DNA chip.
Telomere regulation mechanism and superstructure of protein Pot1 that binds with single strand DNA region in telomeres.
Sumoylation and its function of oncogene product.
Reverse oncology; comprehensive analysis of gene variation by carcinoembryonic LAT1 depressor.
Analysis of carcinogenesis by human papillomavirus.
Molecular mechanism of genomic instability caused by HIV accessory gene Vpr.
Genetic destabilization by continued replication of hepatitis C virus, and analysis of liver carcinogenesis.
Generation of BML disruption strain from human pre-B cells and analysis of its heterologous terminal binding ability.
Research on carcinogenesis by new CREB-binding protein complex in connection with epigenetic genetic regulation.
Molecular mechanism that determines the potency of HTLV-1 and HTLV-2 in causing leukemia.
Function of hepatitis B virus X protein.
Analysis of chromatin assembly mechanism accompanying DNA replication and its correlation with carcinogenesis.
Molecular basis of chromosome segregation control by protein kinase Aurora.
Cell cycle control mechanism in coordination of DNA synthesis and double strand break.
Developmental mechanism of chromosomal aberration through telomere dysfunction.
Molecular mechanism of multistage development of pre B lymphoma.
IL-7 in gastric carcinogenesis by Helicobacter pylori infection.
Prevention of hepatitis and liver carcinogenesis by hepatitis C virus.
Molecular pathogenesis of adult T-cell leukemia.
Performance analysis of genes regulating human papillomavirus in epithelial cells.
Performance analysis of NBS 1 gene as origin of highly carcinogenic hereditary diseases.
Accumulation of intracellular ROS and cancer inhibition by E2F1.
Significance of eukaryotic replication fork in chromosome replication and genome stability.
Performance analysis of lipid-activated nuclear receptor in onset of colon cancer.
Molecular mechanism of translesion synthesis and carcinogenesis.
Molecular structure of DNA replication fork when replication is stopped.
Study of rapamycin target protein mTOR signal controlled by tumor suppressor gene TSC.
Connexin dysfunction in oncogenesis; interdependence with cell adhesion factors.
Development of chromosomal translocation specifically observed in multiple myeloma from molecular biology to biochemistry.
Spontaneous mutation caused by DNA replication errors.
DNA replication-related genes and carcinogenesis.
Performance analysis of gene cluster involved with chromosome stability and homologous DNA recombination.
Influence of telomerase and telomere maintenance on cell immortalization.
Performance analysis of Rev1 involved with DNA replication error in translesion replication.
Defects in homologous recombination repair and carcinogenesis.
Analysis of cell growth control by transcription elongation factor elongin.
Carcinogenesis by dysfunction of biomolecular modification and control.
Gene abnormality in G-protein signal system and carcinogenesis.
Carcinogenesis by HTLV-I using animal model.
Function of novel c-Myc-binding protein MM-1 as tumor suppressor gene product.
Performance analysis of p53 and its target genes.
Clarification of gene abnormality in development and progress of human cancer.
Performance analysis of oncogene by gene targeting.
Malignant degeneration of tumor by anomaly of TGF-beta signal.
High throughput methylation detection system using DNA chip.
Analysis of malignant transformation of lymphocyte by oncogene BCL6.
Isolation of novel tumor suppressor gene from homozygously deleted region of chromosomes in cancer cell.
Analysis of specificity and gene expression of gene mutation induced by carcinogen in environment.
Research of causative gene for hematopoietic cancer using mouse model.
Multistage carcinogenesis research by disorder model.
Analysis of apoptosis induction by p53.
Analysis of ras carcinogenesis through oncogene Nox1.
Analysis of apoptosis induction by tumor suppressor gene product ARF: mechanism of p53-independent apoptosis.
Mechanism of malignant transformation in cancer with weakened expression of p27Kip1.
Analysis of malignant degeneration with focus on adaptor molecule.
Multi-faceted molecular pathological analysis of the onset and progress of human lung carcinogenesis.
Gene mutation in glandular stomach carcinogenesis of H. pylori-infected gerbil.
Induction of mutation in PolK-deficient mice and cell strain.
Pathological research of GIST using c-kit-modified mice.
Crosstalk of circadian rhythm and prevention of cancer.
Research of carcinogenesis using mice with conditional Rac1 deficiency.
Comprehensive analysis of genomic imprinting in connection with carcinogenesis.
Control of cell growth and apoptosis by Bach family.
Analysis of novel Wnt/Fz signal transduction molecule, WISP, and control molecule, Dkk.
Creation of carcinogenesis mouse model by inactivation of tissue-specific Runx, and analysis of molecular mechanism of cancer development.
Research on degradation of cytostatic molecule p27.
Molecular mechanism of activation of NADPH oxidase.
Regulation of cell canceration and cell growth by Myc target gene mina53.
Molecular mechanism of potent carcinogenicity of Bloom's syndrome.
Molecular mechanism of genomic instability in Fanconi anemia and myelodysplastic syndrome.
Isolation and performance analysis of genes associated with hereditary breast cancer.
Genes involved in gastric carcinogenesis.
Research on genetic factor of those with high risk of hereditary cancer.
Causative gene of highly carcinogenic hereditary diseases characterized by precocious sister chromatid separation and mosaic variegated aneuploidy.
Activation of carcinogen, and function and cancer risk of detoxification enzyme.
Function of transcription factor Nrf2 in prevention of carcinogenesis.
Analysis of transcriptional control of EWS, oncogene of Ewing sarcoma, against antioncogene p53.
Identification and performance analysis of chromosome condensation protein.
Influence of p51/63 genes on homeostasis of epithelial cells.
Mechanism of cancer cell's resistance to oxygen and nutrient starvation, and their influence on progress of cancer.
Analysis of repair of UV-damaged DNA using NMR.
The molecular mechanism of defense against carcinogenesis by DNA recombination repair.
Retrieval of gene that is silenced by aberrant methylation in human gastric cancer.
Analysis of carcinogenesis using transgenic rats.
Analysis of urethane-induced pulmonary carcinogenesis in Pol-iota gene transgenic mice. Identification of translesion DNA synthetase gene Pol-iota and pulmonary carcinogenesis-resistant gene Par2.
Research for detection of prevention factor for colon cancer using precancerous changes and apoptosis as indexes.
Analysis of inhibition of genetic homologous recombination by ubiquitin and mechanism for the maintenance of genomic homeostasis.
Research on canceration by a breakdown of stress defense system.
Research on protection against estrogen dependent cancer.
Research on the cytobiological mechanism of a new antioncogene RB1CC1.
Research on the methylation maintenance of genomic DNA.
Abnormality and carcinogenesis susceptibility of the protective mechanism against oxidative DNA lesion.
Oxidative damage and defense of DNA and nucleotide.
Research on recognizing antigen and regulation molecule of helper T cell in rejection of tumor.
Identification of rejection antigens for gastric cancer, pancreatic cancer, and pulmonary cancer and the development of cancer vaccine.
Research on the in vivo immunotolerant regulation in cancer immunization.
Research on the mechanism of signal transmissions of IL-2 and IL-15 that induce the maturation of different CTL functions.
Identification of cancer antigen by expression cloning system (SEREX) using antibody of cancer patient.
Examination on the mechanism of recognition of tumor cells by NK cells.
The activation of Th1 and the enhancement of antitumor immunity by immunological adjuvant.
Conquest of the immunotolerance to virus tumors.
Molecular mechanism of NK cells in recognition and destruction of cancer cells.
Structure and mechanism of a new MHC class I like molecule MILL.
Research on immune surveillance involved in chronic myelogenous leukemia using SPA-1 gene disruption mouse.
Analysis on the diverse activation mechanisms of dendritic cell subpopulations.
Investigation of a new junction for cancer immunity and autoimmunity.
Analysis of cancer rejection antigens that are recognized by human CD8+ killer T cell.
Identification of tumor-specific antigens that are recognized by human T cells.
Induction of gene mutation in B lymphoma by GANP, type 2 RNA primase.
Cancer suppression mechanism of tyrosine phosphatase PTP.EPSILON.C.
Elucidation of mRNA degradation mechanism. Development of detection method for oncogenic genes and its clinical use.
Analysis on inositol phospholipid signal transduction pathway with as focus on the role in oncogenesis.
Signal transduction associated to the microtubule stability regulation, and carcinogenesis.
Functional analysis of Ras protein family with knockout mouse.
Tyrosine phosphorylating protein and proliferation response of cancer cells.
Signal mechanism of tumor associated 4F2 heavy chain antigen (CD98) via mTOR.
Molecular mechanism of signal transduction via hepatocyte growth factor receptor (c-Met).
Cancer cell proliferation and caveolin.
Mechanism of membrane micro domain control. The elucidation by analysis of a novel lipid droplet protein.
The raft structure regulation and proliferation and differentiation signal regulation by sphingoglycolipid.
Functional analysis of the novel Akt binding protein.
Control mechanism of the Ras/MAP kinase pathway-inhibiting factor Sprouty.
Functional analysis on MAP kinase pathway with transgenic mouse.
The signaling mechanism of cell proliferation.
The role of primary transcription factors and intranuclear signaling mechanism in oncogenesis caused by the transcription factor defect.
Longitudinal and spatial control by Rho family G proteins and interactions. Analysis with FRET probe.
Study on the molecular genetics of MAPK pathway with utilization of antagonistic relationship with calcineurin.
Cell proliferation control mechanism of small G-protein.
Oncogenic mechanism associated to the defective morphogenesis signal pathway.
Signaling mechanism for apoptosis and proliferation through TNF family molecules and cytokine.
Functional analysis on ATOM.
Signal pathway for P19 germ cell tumor differentiation.
Functional analysis of the large Maf transcription factors in the cell differentiation and canceration.
Genetic function analysis of Drosophila JNK/p38 and ATF-2 in apoptosis.
The role of FKHRL1 transcription factor in the dormancy induction of leukemic cells.
Cytoskeleton regulation and oncogenesis by novel actin-binding protein Nd1.
Analysis on the function and mutation of sp53 coactivator ING family in cancer cells.
Genetic analysis on apoptosis mechanism through Bax-like molecule, independent of caspase.
Control over cell differentiation and cell death by signal transduction.
The onset mechanism of acute lymphatic leukemia by MLL-AF4 family fusion gene.
Elucidation of DNA damage-induced apoptosis of cancer cells by functional proteomics analysis.
Activation control and physiological significance of apoptosis induction specific p53.
Formation/regression of cancer and programed cell death.
Isolation and functional analysis of p53 target gene, and its application for cancer treatment development.
Cell differentiation and canceration molecular mechanism by translocation-related gene and transcription factor.
Apoptosis inhibitory effect and the cancerogenesis-enhancing effect by transcription factor NF-kappa B.
Molecular mechanism of malignant transformation of cells analysed by inhibition of apoptosis signal through Fas.
Molecular analysis of apoptosis in cancer cell.
Analysis of hematopoietic cancer development by small mutation of AML/RUNX1.
Signal for cellular differentiation and tumorigenesis from receptors.
Function of p27kip1 and NAT1 in IRES-dependent translation.
Signal control of cell differentiation and apoptosis by heat shock transcription factors.
Molecular mechanism of apoptosis supported by Ser/Thr kinase type receptor.
Significance of induction of expression of cycline D1 and canceration by tumor-derived mutant pRB.
Function of ubiquitin ligase Cdc4 of cycline E in cell cycle.
Abnormal cell cycle and frame of leukemia cell.
Cell cycle arrest and cell differentiation by p53.
Elucidation of anchorage-independent replication initiation.
Metergy and fate of target protein by SUMO-1 modification.
Control of cell division and early embryogenesis by Rho family G protein.
Analysis of canceration mechanism by PI3 K-Akt pathway.
Abnormality in cell cycle control.
Abnormal transcription and cell growth and differentiation.
Abnormal negative growth signal and collapse of cell growth control.
Control mechanism of p53 cancer-suppressing protein by oncogene product Mdm2.
Participation of protein-stabilizing novel p27kip1-binding factor in prevention of carcinogenesis.
Clarification of molecular mechanism that provokes chromosome instability in cancer cells.
Analysis of activity control by Chk2 of tumor suppressor gene product p53.
Breakdown of cell cycle control and malignant tumor.
Abnormality in transcriptional control and collapse of cell growth regulation.
Cell proliferation and carcinogenesis viewed from control mechanism of chromosome replication initiator.
Proteolysis in cell cycle, and classification of molecular chaperones.
Analysis of cell growth suppression and its collapse.
Research on growth control of cancer cell using cytokine signal as molecular basis.
Direct participation of epidermal adhesion molecules in invasion and metastasis of skin cancer.
Performance analysis of tumor suppressor gene product PTEN and phosphoinositide in control of cell motility.
Performance analysis of the LIM kinase and Slingshot in elevation of cancer cell motility.
Human cancer and aberration in crosstalk control mechanism of growth signal and adhesion signal in cells.
Performance analysis of protein that conjugates with intracytoplasmic domain of novel CD44 protein.
Metastasis and invasiveness of cancer cell, and their relationship with lysophosphatidic acid.
Novel ubiquitin ligase with specific action to Src family kinase with EVH1-binding sequence.
Invasion control mechanism of extracellular matrix degradation and cancer cell.
Function of beta 1 integrin and its associated molecules (CD9, CD82) in growth, invasion, and metastasis of cancer.
Analysis of osteopontin in connection with bone metastasis of prostate cancer.
Control of osteolytic tumor by suppressing the coupling of osteoclasis and osteogenesis.
Spatial configuration and function of AMF and ATX, stimulators of cancer cell motility.
Control of metastasis and invasion of tumor by substrate molecule of tyrosine kinase.
Cell motility control by phospholipid metabolic enzyme.
Control of cancer cell function by matrix protease.
Role of G protein-coupled receptor in cancer invasion and metastasis, and its molecular mechanism.
Cooperative control of cell motility and MT-MMP in cancer cell invasion.
Cell migration by degradation of actin-binding protein filamin, and its molecular basis.
Activation of invasion and metastasis of cancer cells by Src signal transduction system.
Control of cell adhesion and movement by trimeric GTP-binding protein.
Relationship of fractalkine and its receptor expression with malignancy and metastasis of cancer.
Function of centripetal flow of intracellular actin in cancer cell invasion.
Chemotaxis activation by ADAM protease meltrin.
Control of anchorage-dependent cell growth and invasion by membrane scaffolding protein.
Activity control of Rho family and invasion and metastasis of cancer.
Invasion control of cancer cell through cell adhesion.
Determining exact intracellular localization of Rho family proteins and their change by carcinogenesis.
Invasion control of cancer cell through membrane-bound growth factor and receptor-like tyrosine kinase.
Clarification of signal transduction of CDM family molecules.
Anti-invasion and metastasis therapy using molecules that control extracellular matrix.
Molecular basis of hypoxic response that determines the formation and maintenance of tumor.
(Relation between abnormal histogenesis and cancer) "Research on differentiation control of hematopoietic stem cells in hematopoietic microenvironment".
Hypermorphosis of epithelial tissue and mechanism of carcinogenesis.
Involvement of bone marrow-derived vascular progenitor cells in tumor vascularization.
Expression control of IPAS gene.
Tumorigenesis and maintenance.
Control of vascularization and lymphangiogenesis by angiopoietin molecules.
Molecular basis in vascularization.
Growth and differentiation of hematopoietic stem cell.
Growth differentiators controlling formation of mesenchymal tissue.
Control of cell kinetics of chemokine and action mechanism in angiogenesis.
Interaction between epithelium and mesenchyme responsible for malignant degeneration of cancer.
Control of tumor vascularization by extracellular matrix factor.
Effect of HIF-1 system on cancer growth.
Production of transgenic mouse with active form of hypoxia-responsive transcription factor HIF-1alpha.
Function of novel transcription factor DEC1 in hypoxic response.
Understanding of gene mutation, expression mutation, and multi-stage oncogenesis in serial borderline microlesions from gastrointestinal carcinoma and normal epithelium.
Development of methods for detection and functional evaluation of oncogene mutations.
Basic study for the application of cancer-specific secretory sialic acid transferase to early diagnosis of cancer.
Establishment of genetic diagnosis system for objective diagnosis of lung adenocarcinoma and the malignancy.
Bioinformatic analysis on the characteristics of human colon cancer metastasis using mouse models.
Strategic and individualized treatment for gallbladder cancer and pancreatic cancer using proteomics.
Development of diagnostic method for hepatocellular carcinoma through analysis of gene expression profiles.
Development of individualized diagnosis for cancer through screening of new genomic abnormalities and multi-article genetic information.
Study for a new diagnostic method of hereditary tumor through quantitative comparison of allele-specific gene expression.
Establishment of detection method for peptide tumor markers from blood.
Genetic diagnosis for breast and thyroid cancers based on systematic analysis of genetic abnormality.
Development of a new diagnostic method for gastrointestinal cancer targeting epigenetic abnormalities.
Development of new diagnostic imaging agent for brain tumor using behavior of essential trace elements in living body.
Study on genes that regulated the expression of cell adhesion molecules involved in the hematogenous metastasis of cancer.
Development of genetic diagnosis and treatment for microscopic metastasis in gastric and colon cancers.
Development of gene-analysis system using function nucleic acid.
Genetic diagnosis for breast cancer and the clinical application.
Establishment of diagnosis for gastrointestinal carcinoma based on decomposition suppression of matriptase.
Genetic diagnosis of leukemia and related diseases using WT1 assay.
Understanding of daily rhythm in cell kinetics and development of diagnosis based on clock gene.
Study for the understanding of blastic crisis in chronic myelogenous leukemia and the establishment of early genetic diagnosis.
Development of brain tumor diagnosis using proteome maps of cerebral nervous system.
Induction of antitumor effects through gene modification by dendritic cells.
High expression of NK4 protein under the presence of SLPI expressing lung cancer-selective E1A. Suppression of regional and systemic tumors.
Establishment of gene/cell therapy with adoptive immunity using retroviral vector.
Basic study on the suppression of cancer metastasis by activated NKT cells and the clinical application.
Study on the prevention of GVHD and the selective induction of GVL/T targeting chemokine.
Development of new cellular immunotherapy for leukemia.
Induction of tumor-specific immunity using a nonspecific immune mechanism.
Development of immunotherapy for human adult T-cell leukemia using rat models.
Development of new immunotherapy for melanoma.
Regulation of phylaxis by functional adjustment of NK cells and NKT cells.
Development of immunotherapy model targeting mouse TL antigen.
Cancer treatment by peptide antigens that derive from oncogene products.
Development of new antitumor immunotherapy through isolation of PD-1/PD-L1 system and use of non-peptide antigen.
Anti-cancer immunity therapy by activation of innate immunity.
Identification of tumor antigens and analysis of immune responses by the host.
Clinical study on MUC1-stimulated dendritic cell therapy for pancreatic cancer. Research with microarray analysis of dendritic cells.
Genetic immunotherapy for epithelial cancer targeting mucin molecule.
Study on the enhancement of cancer immunity by regulation of Jagged1.
Development of new genetic immunotherapy for leukemia.
Study on cancer gene vaccine development by application of ubiquitin proteasome system.
Significance of RCAS1 molecule in deviation from the immunological surveillance of cancer.
Cancer immunity treatment study based on functional analysis of the molecular chaperone in MHC diversity and antigen presentation.
Basic research on RNA interference by 4'-thioRNA and its application to cancer gene therapy.
Development of EB virus vector aiming at application to immunity gene therapy of cancer.
Development of gene therapy method which aims at specific targeting of tumor.
Gene therapy of cancer by peptide nucleic acid to which membrane-permeable peptide is added.
Development of adeno-associated virus (AAV) vector and its application to cancer gene therapy.
Development of tumor-selective amplification type hybrid virus vector and elucidation of its control mechanism.
Development of RNA interference in mammal cell using PolIII expression system, and its application to cancer treatment.
Development of methods for the selective amplification of effector and dendritic cells for the enhancement of antitumor activity.
Development of adenoviral vectors and methods to control the expression for the treatment of cancer.
New retroviral vector that expresses antioncogene at high levels for long periods and the production system of the vectors.
Development of HIV vectors.
Application of atelocollagen embedding method.
Development of adenoviral vector system specifically targeted to cancer.
Gene therapy by positively charged liposome using biosurfactant.
Development of gene therapies for metastatic cancer through the enhancement of long-term expression of transgenes.
Cytokine therapies for cancer through highly efficient gene transduction by administration of plasmid solution.
Creation of ultra-functionality artificial oligonucleotide for gene therapies for cancer.
Development of new method of in-vivo pinpoint gene transduction with nano particles fused with living body-recognizing molecules.
Creation of multifunctional non-viral vectors. Integration of gene expression promoters and promotion mechanism for nuclear-localization.
Development of cancer therapies by protein replacement using protein transduction method and cell membrane-permeable peptide nucleic acid.
Establishment of pre-clinical common marmoset models for the development of clinical vectors for gene transduction.
Establishment of the molecular targeted therapy for cancer using apoptosis-related molecules.
Development of new antitumor therapy targeting GST-pi.
Analysis and clinical application of the molecular mechanism in TRAIL-resistance.
Molecular-genetic study on the analgesic effect of morphine to cancer pain and the occurrence of side effects.
New theory for the creation of effective photosensitizer in photodynamic therapies for cancer.
Efficient design of antisense oligonucleotide for molecular targeted therapies for cancer.
Analysis of the molecular mechanism of 12p13 translocation leukemia.
Diagnosis and treatment for cancer using labeled antibody.
Analysis of action mechanism of differentiation inducer and examination of therapeutic effects.
Investigation of new molecular targets involved in the canceration of cells and analysis of intracellular functions using libozyme library.
Identification of molecular target for new terapy and diagnosis for sex hormone-dependent cancer andthe application.
Development of a chemotherapeutics that are functional only in cancer cells, based on a completely new theory.
Investigation of caspase-independent apoptosis derivatives and the molecular mechanism.
Correlation analysis of the gene mutation polymorphisms in drug-metabolizing enzymes and the intensity of pharmacological reactions by anticancer agents.
Gene expression of ganglioside GM3 synthetase and its biological functions.
Molecular-biological research on the control of drug sensitivity and resistance.
Research on resistance and sensitivity to antitumor agents using retrovirus gene transduction.
Mechanism of telomere length control by tankyrase and suppression of cancer by telomerase inhibitor.
Investigation of antitumor agents targeted to internal apoptosis inhibitor in cancer cells.
Analysis on the resistance mechanism of apoptosis in chemotherapy and antibody therapy.
Establishment of new cancer treatment by biologically fused nanoparticle which have radical developmental functions.
Development and evaluation of a leukemia-selective molecular-targeted therapy.
Preclinical examinations on antibody therapies and cancer.
Study on new lung cancer therapy by RNAi targeting molecular characteristics of cancer cells.
Development of new molecular targeted therapy for multiple-drug-resistant leukemia.
Development of cancer treatment targeting HSCO and gankyrin that are excessively expressed in hepatic cancer.
Suppression of cancer metastasis by cell-specific gene transfer therapy targeted for oxygen radical elimination enzyme.
Gastrointestinal-carcinoma therapy by TCF decoy targeted at Wnt signal transcriptional activity.
Development of anti-apoptosis drug targeted at permeability-increasing mechanism of mitochondrial membrane.
Development of therapy targeted at the activating mutation of c-Kit and abnormal signal transduction of Flt3.
New type of drugs to prevent cancer metastasis.
Development of new oncolytic virus therapy targeted at telomerase activity, and analysis on its interaction with chemotherapy.
Biological therapy of lung cancer, targeted at the metastasis and neovascularization-related molecules.
Cancer therapy with synthetic hybrid ubiquitin coupling enzyme.
Tailored cancer therapy targeted at the molecules related to drug sensitivity and neovascularization.
Suppression by hypoxia of radiation-induced apoptosis signal, and hypoxia radiosensitizing agent. Focused on the expression of radiation induction TNF receptor.
NF-.KAPPA.B-related radiosensitizing mechanism of radioresistant cancer cells.
Mechanism of radiation induced apoptosis and estimation of the sensibility.
Basic analysis of stress response mechanism upon the exposure to radiation and high temperature.
DNA-PK, ATM transcriptional control analysis and the radiosensitivity regulation and prediction using the result.
Signal transduction of the DNA-PK-dependent repair system in radiation-induced DNA damage, and application in the cancer radiotherapy.
Analysis of the radioresistant signal transduction mechanism by IGF-I receptor.
Development of therapy by radiation induced apoptosis.
Involvement of poly (ADP ribose) metabolism in the body and cell level radiation response, and radiosensitization.
Basic study on gene transfer and apoptosis induction for ultrasound cancer therapy.
The role of the radiation induced Bystander effect by NO radical in radiotherapy.
Development of the cancer treatment using the molecular chaperone induced by high temperature.
Prediction of tumor hypoxic fraction and new therapy strategy for overcoming the radiotherapy resistance.
Radiotherapy for intractable cancers using the recombination gene (Rad51).
Basic research on neutron capture therapy for the X-ray-hyposensitive tumors.
Radiosensitivity control mechanism of malignant lymphoma by oncogene products and antioncogene products.
Basic study on radiation and high temperature cancer treatment combined with the molecular chaperone.
Design of anticancerous nucleic acid derivatives, based on structure, sequence, and metabolic information.
Search for new anticancer drug leading compounds targeted at growth factor REG.
Elucidation of molecular markers for anticancerous substances found in new medicinal resources.
Study on the cancer growth environment modifiers.
Search for novel molecular targets for anticancer drugs among the new natural resources.
Cancer suppression strategy with functional RNAs.
Creation of medicinal leading molecules which inhibit cancer aggravation factors.
Search for novel compounds that inhibit proliferation signal transduction.
Search for anticancer agents targeted at apoptosis resistance of cancer cells.
Overcoming the stress induced drug resistance targeted at proteosome protein degradation pathway.
Analysis on the canceration signal transduction, and search for leading molecules for anticancer drugs.
Action mechanism of antitumor agents obtained from natural resources, and the evaluation on disease models.
Search for new target molecules for the cancer therapy by bioinformatics.
Search for substances that suppress the malignant alteration to cancer cells.
New search method for CTL immunoinducing anticancer agents, using natural melanoma mouse.
Development of practical CXCR4 antagonist for antimetastasis drugs.
Development of tailor-made anticancer drugs that correctly recognize DNA sequence.
Development of telomerase inhibitor, based on the new conception "telomere knot" formation.
Analysis on control of cancer invasion and metastasis by altering integrin sugar chain, and its molecular mechanism.
Cancer therapy with novel interferon-like protein Limitin that causes less myelosuppression.
Development of new canceration inducing agents targeted at cell cycle regulation.
Development of small molecule cancer suppresser molecules and IL-6 inhibiting human antibodies with phage library.
Significance of amplified MTH1 expression in human cancer cells, and the suprression of MTH1 expression and the function.
Search for new molecular target in cancer cell response related to DNA disorders.
Search for cell proliferation inhiviting agents targeted at signaling molecules for MAP kinase cascade.
Anticancer drugs targeted at the zinc site on Ras farnesyl transferase.
Development of new drugs to suppress proliferation, invasion, and metastasis of tumors.
Morbidity of fat-related cancers in the people of Northern Europe and North Polar Region, and elucidation of environmental and host-related factors.
Cancer epidemiology of Japanese immigrants in Brazil.
Anthropological study on EB herpes virus-related cancer in Asia.
Epidemiological cooperative research on the correlation between hepatolithiasis and intrahepatic cholangiocarcinoma in Taiwan.
Host and environment factors associated to gastrointestinal cancers in 3 Southeast Asia Countries.
Comparative epidemiological study on Gastrointestinal Cancer in Japan, China, and South Korea.
Epidemiological analysis on the onset factors of nasal NK/T-cell lymphoma.
Molecular epidemiological study on basal cell carcinoma of skin in East Kazakhstan State of Republic of Kazakhstan.
Molecular epidemiological study on thyroid cancer in Chernobyl and the surrounding region.
Onset factors for cancers in the Pacific Rim region.
Cohort study on the correlation between the folic acid intake and the onset of colon and breast cancers.
Cohort study on HPV infection and uterocervical oncogenesis.
Epidemiological research on the environment and host factors of prostatic cancer.
Study on living environment factors and serum estrogen for the breast cancer prevention.
Large scale cohort study on the onset of colon cancer and fatality factors.
Large-scale cohort study on serum components associated to the risk of prostatic cancer, urinary tract epithelial cancer, and renal cancer.
Nested case control study on breast cancer among the victims of nuclear exposure, using the preserved serum samples.
Case-control study on lifestyle factors associated to colon cancer.
Epidemiological study on the risk factors of liver cancer based on the result data of large-scale cohort study.
Development of gastric mucosal lesion and Helicobacter pylori. With a focus on the association with gastric cancer.
Molecular epidemiological search for immune response to the target gene mutations in the cancer associated to the genetic instability.
Case-control study on gene polymorphism associated to parasite-related biliary tract cancer in Thailand.
Research on the risk of secondary development of primary-carcinoma arising from gastrointestinal cancer with a focus on the host and the environment-related factors.
Molecular epidemiological technique to determine the pathology of familial endometrial carcinoma and genetic diagnosis.
Cancer and prevention research on nuclear acceptor protein as the target molecule.
The host/environmental interaction and cancer susceptibility based on metabolic enzyme gene polymorphism.
Molecular epidemiological analysis and risk model of urinary tumors with a focus on prostatic cancer.
Analysis on the gene polymorphism involved in the onset risk of urinary cancer and the sensitivity of cancer cell s to therapy.
Mitochondrial genome analysis and comprehensive cancer risk management.
Research on the individual differences and the host and environment factors associated to the expression of oncogenes.
Molecular epidemiological research on the host factor associated to virus-related oncogenesis.
Research on the molecules involved in the progression of gastrointestinal carcinoma, and the therapy and prognosis.
Molecular epidemiological study on the types and progression of melanoma in Japanese population.
Diagnosis and therapy of liver cancer with the use of biological markers. Clinical epidemiological study.
Characteristics of lymphomas seen in Japanese population, with a focus on the Herpesvirus-related lymphomas.
International research to create new taxonomy for T / NK cell lymphomas, with bioinformatics.
Study on the biological prognostic factors associated to hematologic neoplasm.
Search for the genes associated to esophageal cancer and gastric cancer with SAGE, and their significance in the onset, progression, and prognosis.
Clinical epidemiology and grade of malignancy of squamous-epithelium cancer.
Kinetic and performance analysis of hormone DHEA involved in the progression to myeloma from precancerous lesion BMG.
Clinical epidemiological study on the expression of mucin gene, new adhesion factor, and prognosis in human cancer.
Long-term followup study on the high risk group of ATL and the onset prevention.
Regulation of the proliferation and the canceration of cells through the phosphorylation and the dephosphorylation of proteins.
Regulation mechanisms for the proliferation and differentiation of cells by cancer-associated genes.
Molecular mechanisms of signal transduction that regulates the proliferation, differentiation, and cycle of cells.
Signal transduction in regulation of cell movement and cytoskeleton.
Molecular mechanism in cell adhesion of epithelial cells and signaling of cell polarity.
Molecular mechanism and abnormality in intercellular adhesion. Roles in cancerization, metastasis, and invasion.
Identification and functional analysis of a new molecular group that regulates the dynamics of cancer cells.
Molecular mechanism for generation, proliferation, and differentiation of hepatocytes.
Study on interactions between epithelium and stroma in carcinogenesis.
Molecular mechanism in regulation of cancerism.
Differentiation of ES cells for understanding of formation mechanism of blood/vessel system and treatment of cells.
Role of transcription factors in the cancerization of cells and the inhibition of cancerization.
Gene expression network involved in cancer inhibition.
Analysis of correlation between RB pathway and p53 pathway.
Analysis on the regulation of cell proliferation by EGF family and the abnormal proliferation due to breakdown of the regulation.
Molecular mechanism of TGF-beta signal and its abnormality in human cancer.
Separation of intracellular signal molecule and analysis of the abnormality in human cancer.
Regulation mechanism for tyrosine kinase signals.
Development of method for cancer inhibition based on regulation of chromatin structure and its functions.
Study on molecular mechanism of regulation in intranuclear receptor transcription.
Analysis of the molecular mechanism and the physiological functions of apoptosis.