List of Jounal Titles
A to Z index of Journal Title. Choose a letter.
Gan Kenkyu ni kakawaru Tokutei Ryoiki Kenkyu Kenkyu Hokoku Shuroku Heisei 15 Nendo (CD-ROM)
- Research on EB virus and development of gastric cancer.
- Analysis of onset mechanism of gastric cancer initiated by Helicobacter Pylori bacterial infection.
- Mechanism of Igf2LOI in hepatoma cells of clone mouse.
- Analysis of inhibition of gene expression by DNA methylation in gastrointestinal cancer.
- Analysis of mutant genes with chromosomal aberration using model organisms.
- Cell canceration ability of a chromatin-remodeling factor and nucleoporin fused oncogene.
- Active domain of homologous recombination in tumor-suppressing DNA repair protein.
- Molecular control mechanism and carcinogenesis of p53 by stability of p73 and delta Np73.
- Carcinogenesis of liver cancer by hepatitis C virus.
- Analysis of molecular mechanism of translocation leukemia by using DNA chip.
- Telomere regulation mechanism and superstructure of protein Pot1 that binds with single strand DNA region in telomeres.
- Sumoylation and its function of oncogene product.
- Reverse oncology; comprehensive analysis of gene variation by carcinoembryonic LAT1 depressor.
- Analysis of carcinogenesis by human papillomavirus.
- Molecular mechanism of genomic instability caused by HIV accessory gene Vpr.
- Genetic destabilization by continued replication of hepatitis C virus, and analysis of liver carcinogenesis.
- Generation of BML disruption strain from human pre-B cells and analysis of its heterologous terminal binding ability.
- Research on carcinogenesis by new CREB-binding protein complex in connection with epigenetic genetic regulation.
- Molecular mechanism that determines the potency of HTLV-1 and HTLV-2 in causing leukemia.
- Function of hepatitis B virus X protein.
- Analysis of chromatin assembly mechanism accompanying DNA replication and its correlation with carcinogenesis.
- Molecular basis of chromosome segregation control by protein kinase Aurora.
- Cell cycle control mechanism in coordination of DNA synthesis and double strand break.
- Developmental mechanism of chromosomal aberration through telomere dysfunction.
- Molecular mechanism of multistage development of pre B lymphoma.
- IL-7 in gastric carcinogenesis by Helicobacter pylori infection.
- Prevention of hepatitis and liver carcinogenesis by hepatitis C virus.
- Molecular pathogenesis of adult T-cell leukemia.
- Performance analysis of genes regulating human papillomavirus in epithelial cells.
- Performance analysis of NBS 1 gene as origin of highly carcinogenic hereditary diseases.
- Accumulation of intracellular ROS and cancer inhibition by E2F1.
- Significance of eukaryotic replication fork in chromosome replication and genome stability.
- Performance analysis of lipid-activated nuclear receptor in onset of colon cancer.
- Molecular mechanism of translesion synthesis and carcinogenesis.
- Molecular structure of DNA replication fork when replication is stopped.
- Study of rapamycin target protein mTOR signal controlled by tumor suppressor gene TSC.
- Connexin dysfunction in oncogenesis; interdependence with cell adhesion factors.
- Development of chromosomal translocation specifically observed in multiple myeloma from molecular biology to biochemistry.
- Spontaneous mutation caused by DNA replication errors.
- DNA replication-related genes and carcinogenesis.
- Performance analysis of gene cluster involved with chromosome stability and homologous DNA recombination.
- Influence of telomerase and telomere maintenance on cell immortalization.
- Performance analysis of Rev1 involved with DNA replication error in translesion replication.
- Defects in homologous recombination repair and carcinogenesis.
- Analysis of cell growth control by transcription elongation factor elongin.
- Carcinogenesis by dysfunction of biomolecular modification and control.
- Gene abnormality in G-protein signal system and carcinogenesis.
- Carcinogenesis by HTLV-I using animal model.
- Function of novel c-Myc-binding protein MM-1 as tumor suppressor gene product.
- Performance analysis of p53 and its target genes.
- Clarification of gene abnormality in development and progress of human cancer.
- Performance analysis of oncogene by gene targeting.
- Malignant degeneration of tumor by anomaly of TGF-beta signal.
- High throughput methylation detection system using DNA chip.
- Analysis of malignant transformation of lymphocyte by oncogene BCL6.
- Isolation of novel tumor suppressor gene from homozygously deleted region of chromosomes in cancer cell.
- Analysis of specificity and gene expression of gene mutation induced by carcinogen in environment.
- Research of causative gene for hematopoietic cancer using mouse model.
- Multistage carcinogenesis research by disorder model.
- Analysis of apoptosis induction by p53.
- Analysis of ras carcinogenesis through oncogene Nox1.
- Analysis of apoptosis induction by tumor suppressor gene product ARF: mechanism of p53-independent apoptosis.
- Mechanism of malignant transformation in cancer with weakened expression of p27Kip1.
- Analysis of malignant degeneration with focus on adaptor molecule.
- Multi-faceted molecular pathological analysis of the onset and progress of human lung carcinogenesis.
- Gene mutation in glandular stomach carcinogenesis of H. pylori-infected gerbil.
- Induction of mutation in PolK-deficient mice and cell strain.
- Pathological research of GIST using c-kit-modified mice.
- Crosstalk of circadian rhythm and prevention of cancer.
- Research of carcinogenesis using mice with conditional Rac1 deficiency.
- Comprehensive analysis of genomic imprinting in connection with carcinogenesis.
- Control of cell growth and apoptosis by Bach family.
- Analysis of novel Wnt/Fz signal transduction molecule, WISP, and control molecule, Dkk.
- Creation of carcinogenesis mouse model by inactivation of tissue-specific Runx, and analysis of molecular mechanism of cancer development.
- Research on degradation of cytostatic molecule p27.
- Molecular mechanism of activation of NADPH oxidase.
- Regulation of cell canceration and cell growth by Myc target gene mina53.
- Molecular mechanism of potent carcinogenicity of Bloom's syndrome.
- Molecular mechanism of genomic instability in Fanconi anemia and myelodysplastic syndrome.
- Isolation and performance analysis of genes associated with hereditary breast cancer.
- Genes involved in gastric carcinogenesis.
- Research on genetic factor of those with high risk of hereditary cancer.
- Causative gene of highly carcinogenic hereditary diseases characterized by precocious sister chromatid separation and mosaic variegated aneuploidy.
- Activation of carcinogen, and function and cancer risk of detoxification enzyme.
- Function of transcription factor Nrf2 in prevention of carcinogenesis.
- Analysis of transcriptional control of EWS, oncogene of Ewing sarcoma, against antioncogene p53.
- Identification and performance analysis of chromosome condensation protein.
- Influence of p51/63 genes on homeostasis of epithelial cells.
- Mechanism of cancer cell's resistance to oxygen and nutrient starvation, and their influence on progress of cancer.
- Analysis of repair of UV-damaged DNA using NMR.
- The molecular mechanism of defense against carcinogenesis by DNA recombination repair.
- Retrieval of gene that is silenced by aberrant methylation in human gastric cancer.
- Analysis of carcinogenesis using transgenic rats.
- Analysis of urethane-induced pulmonary carcinogenesis in Pol-iota gene transgenic mice. Identification of translesion DNA synthetase gene Pol-iota and pulmonary carcinogenesis-resistant gene Par2.
- Research for detection of prevention factor for colon cancer using precancerous changes and apoptosis as indexes.
- Analysis of inhibition of genetic homologous recombination by ubiquitin and mechanism for the maintenance of genomic homeostasis.
- Research on canceration by a breakdown of stress defense system.
- Research on protection against estrogen dependent cancer.
- Research on the cytobiological mechanism of a new antioncogene RB1CC1.
- Research on the methylation maintenance of genomic DNA.
- Abnormality and carcinogenesis susceptibility of the protective mechanism against oxidative DNA lesion.
- Oxidative damage and defense of DNA and nucleotide.
- Research on recognizing antigen and regulation molecule of helper T cell in rejection of tumor.
- Identification of rejection antigens for gastric cancer, pancreatic cancer, and pulmonary cancer and the development of cancer vaccine.
- Research on the in vivo immunotolerant regulation in cancer immunization.
- Research on the mechanism of signal transmissions of IL-2 and IL-15 that induce the maturation of different CTL functions.
- Identification of cancer antigen by expression cloning system (SEREX) using antibody of cancer patient.
- Examination on the mechanism of recognition of tumor cells by NK cells.
- The activation of Th1 and the enhancement of antitumor immunity by immunological adjuvant.
- Conquest of the immunotolerance to virus tumors.
- Molecular mechanism of NK cells in recognition and destruction of cancer cells.
- Structure and mechanism of a new MHC class I like molecule MILL.
- Research on immune surveillance involved in chronic myelogenous leukemia using SPA-1 gene disruption mouse.
- Analysis on the diverse activation mechanisms of dendritic cell subpopulations.
- Investigation of a new junction for cancer immunity and autoimmunity.
- Analysis of cancer rejection antigens that are recognized by human CD8+ killer T cell.
- Identification of tumor-specific antigens that are recognized by human T cells.
- Induction of gene mutation in B lymphoma by GANP, type 2 RNA primase.
- Cancer suppression mechanism of tyrosine phosphatase PTP.EPSILON.C.
- Elucidation of mRNA degradation mechanism. Development of detection method for oncogenic genes and its clinical use.
- Analysis on inositol phospholipid signal transduction pathway with as focus on the role in oncogenesis.
- Signal transduction associated to the microtubule stability regulation, and carcinogenesis.
- Functional analysis of Ras protein family with knockout mouse.
- Tyrosine phosphorylating protein and proliferation response of cancer cells.
- Signal mechanism of tumor associated 4F2 heavy chain antigen (CD98) via mTOR.
- Molecular mechanism of signal transduction via hepatocyte growth factor receptor (c-Met).
- Cancer cell proliferation and caveolin.
- Mechanism of membrane micro domain control. The elucidation by analysis of a novel lipid droplet protein.
- The raft structure regulation and proliferation and differentiation signal regulation by sphingoglycolipid.
- Functional analysis of the novel Akt binding protein.
- Control mechanism of the Ras/MAP kinase pathway-inhibiting factor Sprouty.
- Functional analysis on MAP kinase pathway with transgenic mouse.
- The signaling mechanism of cell proliferation.
- The role of primary transcription factors and intranuclear signaling mechanism in oncogenesis caused by the transcription factor defect.
- Longitudinal and spatial control by Rho family G proteins and interactions. Analysis with FRET probe.
- Study on the molecular genetics of MAPK pathway with utilization of antagonistic relationship with calcineurin.
- Cell proliferation control mechanism of small G-protein.
- Oncogenic mechanism associated to the defective morphogenesis signal pathway.
- Signaling mechanism for apoptosis and proliferation through TNF family molecules and cytokine.
- Functional analysis on ATOM.
- Signal pathway for P19 germ cell tumor differentiation.
- Functional analysis of the large Maf transcription factors in the cell differentiation and canceration.
- Genetic function analysis of Drosophila JNK/p38 and ATF-2 in apoptosis.
- The role of FKHRL1 transcription factor in the dormancy induction of leukemic cells.
- Cytoskeleton regulation and oncogenesis by novel actin-binding protein Nd1.
- Analysis on the function and mutation of sp53 coactivator ING family in cancer cells.
- Genetic analysis on apoptosis mechanism through Bax-like molecule, independent of caspase.
- Control over cell differentiation and cell death by signal transduction.
- The onset mechanism of acute lymphatic leukemia by MLL-AF4 family fusion gene.
- Elucidation of DNA damage-induced apoptosis of cancer cells by functional proteomics analysis.
- Activation control and physiological significance of apoptosis induction specific p53.
- Formation/regression of cancer and programed cell death.
- Isolation and functional analysis of p53 target gene, and its application for cancer treatment development.
- Cell differentiation and canceration molecular mechanism by translocation-related gene and transcription factor.
- Apoptosis inhibitory effect and the cancerogenesis-enhancing effect by transcription factor NF-kappa B.
- Molecular mechanism of malignant transformation of cells analysed by inhibition of apoptosis signal through Fas.
- Molecular analysis of apoptosis in cancer cell.
- Analysis of hematopoietic cancer development by small mutation of AML/RUNX1.
- Signal for cellular differentiation and tumorigenesis from receptors.
- Function of p27kip1 and NAT1 in IRES-dependent translation.
- Signal control of cell differentiation and apoptosis by heat shock transcription factors.
- Molecular mechanism of apoptosis supported by Ser/Thr kinase type receptor.
- Significance of induction of expression of cycline D1 and canceration by tumor-derived mutant pRB.
- Function of ubiquitin ligase Cdc4 of cycline E in cell cycle.
- Abnormal cell cycle and frame of leukemia cell.
- Cell cycle arrest and cell differentiation by p53.
- Elucidation of anchorage-independent replication initiation.
- Metergy and fate of target protein by SUMO-1 modification.
- Control of cell division and early embryogenesis by Rho family G protein.
- Analysis of canceration mechanism by PI3 K-Akt pathway.
- Abnormality in cell cycle control.
- Abnormal transcription and cell growth and differentiation.
- Abnormal negative growth signal and collapse of cell growth control.
- Control mechanism of p53 cancer-suppressing protein by oncogene product Mdm2.
- Participation of protein-stabilizing novel p27kip1-binding factor in prevention of carcinogenesis.
- Clarification of molecular mechanism that provokes chromosome instability in cancer cells.
- Analysis of activity control by Chk2 of tumor suppressor gene product p53.
- Breakdown of cell cycle control and malignant tumor.
- Abnormality in transcriptional control and collapse of cell growth regulation.
- Cell proliferation and carcinogenesis viewed from control mechanism of chromosome replication initiator.
- Proteolysis in cell cycle, and classification of molecular chaperones.
- Analysis of cell growth suppression and its collapse.
- Research on growth control of cancer cell using cytokine signal as molecular basis.
- Direct participation of epidermal adhesion molecules in invasion and metastasis of skin cancer.
- Performance analysis of tumor suppressor gene product PTEN and phosphoinositide in control of cell motility.
- Performance analysis of the LIM kinase and Slingshot in elevation of cancer cell motility.
- Human cancer and aberration in crosstalk control mechanism of growth signal and adhesion signal in cells.
- Performance analysis of protein that conjugates with intracytoplasmic domain of novel CD44 protein.
- Metastasis and invasiveness of cancer cell, and their relationship with lysophosphatidic acid.
- Novel ubiquitin ligase with specific action to Src family kinase with EVH1-binding sequence.
- Invasion control mechanism of extracellular matrix degradation and cancer cell.
- Function of beta 1 integrin and its associated molecules (CD9, CD82) in growth, invasion, and metastasis of cancer.
- Analysis of osteopontin in connection with bone metastasis of prostate cancer.
- Control of osteolytic tumor by suppressing the coupling of osteoclasis and osteogenesis.
- Spatial configuration and function of AMF and ATX, stimulators of cancer cell motility.
- Control of metastasis and invasion of tumor by substrate molecule of tyrosine kinase.
- Cell motility control by phospholipid metabolic enzyme.
- Control of cancer cell function by matrix protease.
- Role of G protein-coupled receptor in cancer invasion and metastasis, and its molecular mechanism.
- Cooperative control of cell motility and MT-MMP in cancer cell invasion.
- Cell migration by degradation of actin-binding protein filamin, and its molecular basis.
- Activation of invasion and metastasis of cancer cells by Src signal transduction system.
- Control of cell adhesion and movement by trimeric GTP-binding protein.
- Relationship of fractalkine and its receptor expression with malignancy and metastasis of cancer.
- Function of centripetal flow of intracellular actin in cancer cell invasion.
- Chemotaxis activation by ADAM protease meltrin.
- Control of anchorage-dependent cell growth and invasion by membrane scaffolding protein.
- Activity control of Rho family and invasion and metastasis of cancer.
- Invasion control of cancer cell through cell adhesion.
- Determining exact intracellular localization of Rho family proteins and their change by carcinogenesis.
- Invasion control of cancer cell through membrane-bound growth factor and receptor-like tyrosine kinase.
- Clarification of signal transduction of CDM family molecules.
- Anti-invasion and metastasis therapy using molecules that control extracellular matrix.
- Molecular basis of hypoxic response that determines the formation and maintenance of tumor.
- (Relation between abnormal histogenesis and cancer) "Research on differentiation control of hematopoietic stem cells in hematopoietic microenvironment".
- Hypermorphosis of epithelial tissue and mechanism of carcinogenesis.
- Involvement of bone marrow-derived vascular progenitor cells in tumor vascularization.
- Expression control of IPAS gene.
- Tumorigenesis and maintenance.
- Control of vascularization and lymphangiogenesis by angiopoietin molecules.
- Molecular basis in vascularization.
- Growth and differentiation of hematopoietic stem cell.
- Growth differentiators controlling formation of mesenchymal tissue.
- Control of cell kinetics of chemokine and action mechanism in angiogenesis.
- Interaction between epithelium and mesenchyme responsible for malignant degeneration of cancer.
- Control of tumor vascularization by extracellular matrix factor.
- Effect of HIF-1 system on cancer growth.
- Production of transgenic mouse with active form of hypoxia-responsive transcription factor HIF-1alpha.
- Function of novel transcription factor DEC1 in hypoxic response.
- Understanding of gene mutation, expression mutation, and multi-stage oncogenesis in serial borderline microlesions from gastrointestinal carcinoma and normal epithelium.
- Development of methods for detection and functional evaluation of oncogene mutations.
- Basic study for the application of cancer-specific secretory sialic acid transferase to early diagnosis of cancer.
- Establishment of genetic diagnosis system for objective diagnosis of lung adenocarcinoma and the malignancy.
- Bioinformatic analysis on the characteristics of human colon cancer metastasis using mouse models.
- Strategic and individualized treatment for gallbladder cancer and pancreatic cancer using proteomics.
- Development of diagnostic method for hepatocellular carcinoma through analysis of gene expression profiles.
- Development of individualized diagnosis for cancer through screening of new genomic abnormalities and multi-article genetic information.
- Study for a new diagnostic method of hereditary tumor through quantitative comparison of allele-specific gene expression.
- Establishment of detection method for peptide tumor markers from blood.
- Genetic diagnosis for breast and thyroid cancers based on systematic analysis of genetic abnormality.
- Development of a new diagnostic method for gastrointestinal cancer targeting epigenetic abnormalities.
- Development of new diagnostic imaging agent for brain tumor using behavior of essential trace elements in living body.
- Study on genes that regulated the expression of cell adhesion molecules involved in the hematogenous metastasis of cancer.
- Development of genetic diagnosis and treatment for microscopic metastasis in gastric and colon cancers.
- Development of gene-analysis system using function nucleic acid.
- Genetic diagnosis for breast cancer and the clinical application.
- Establishment of diagnosis for gastrointestinal carcinoma based on decomposition suppression of matriptase.
- Genetic diagnosis of leukemia and related diseases using WT1 assay.
- Understanding of daily rhythm in cell kinetics and development of diagnosis based on clock gene.
- Study for the understanding of blastic crisis in chronic myelogenous leukemia and the establishment of early genetic diagnosis.
- Development of brain tumor diagnosis using proteome maps of cerebral nervous system.
- Induction of antitumor effects through gene modification by dendritic cells.
- High expression of NK4 protein under the presence of SLPI expressing lung cancer-selective E1A. Suppression of regional and systemic tumors.
- Establishment of gene/cell therapy with adoptive immunity using retroviral vector.
- Basic study on the suppression of cancer metastasis by activated NKT cells and the clinical application.
- Study on the prevention of GVHD and the selective induction of GVL/T targeting chemokine.
- Development of new cellular immunotherapy for leukemia.
- Induction of tumor-specific immunity using a nonspecific immune mechanism.
- Development of immunotherapy for human adult T-cell leukemia using rat models.
- Development of new immunotherapy for melanoma.
- Regulation of phylaxis by functional adjustment of NK cells and NKT cells.
- Development of immunotherapy model targeting mouse TL antigen.
- Cancer treatment by peptide antigens that derive from oncogene products.
- Development of new antitumor immunotherapy through isolation of PD-1/PD-L1 system and use of non-peptide antigen.
- Anti-cancer immunity therapy by activation of innate immunity.
- Identification of tumor antigens and analysis of immune responses by the host.
- Clinical study on MUC1-stimulated dendritic cell therapy for pancreatic cancer. Research with microarray analysis of dendritic cells.
- Genetic immunotherapy for epithelial cancer targeting mucin molecule.
- Study on the enhancement of cancer immunity by regulation of Jagged1.
- Development of new genetic immunotherapy for leukemia.
- Study on cancer gene vaccine development by application of ubiquitin proteasome system.
- Significance of RCAS1 molecule in deviation from the immunological surveillance of cancer.
- Cancer immunity treatment study based on functional analysis of the molecular chaperone in MHC diversity and antigen presentation.
- Basic research on RNA interference by 4'-thioRNA and its application to cancer gene therapy.
- Development of EB virus vector aiming at application to immunity gene therapy of cancer.
- Development of gene therapy method which aims at specific targeting of tumor.
- Gene therapy of cancer by peptide nucleic acid to which membrane-permeable peptide is added.
- Development of adeno-associated virus (AAV) vector and its application to cancer gene therapy.
- Development of tumor-selective amplification type hybrid virus vector and elucidation of its control mechanism.
- Development of RNA interference in mammal cell using PolIII expression system, and its application to cancer treatment.
- Development of methods for the selective amplification of effector and dendritic cells for the enhancement of antitumor activity.
- Development of adenoviral vectors and methods to control the expression for the treatment of cancer.
- New retroviral vector that expresses antioncogene at high levels for long periods and the production system of the vectors.
- Development of HIV vectors.
- Application of atelocollagen embedding method.
- Development of adenoviral vector system specifically targeted to cancer.
- Gene therapy by positively charged liposome using biosurfactant.
- Development of gene therapies for metastatic cancer through the enhancement of long-term expression of transgenes.
- Cytokine therapies for cancer through highly efficient gene transduction by administration of plasmid solution.
- Creation of ultra-functionality artificial oligonucleotide for gene therapies for cancer.
- Development of new method of in-vivo pinpoint gene transduction with nano particles fused with living body-recognizing molecules.
- Creation of multifunctional non-viral vectors. Integration of gene expression promoters and promotion mechanism for nuclear-localization.
- Development of cancer therapies by protein replacement using protein transduction method and cell membrane-permeable peptide nucleic acid.
- Establishment of pre-clinical common marmoset models for the development of clinical vectors for gene transduction.
- Establishment of the molecular targeted therapy for cancer using apoptosis-related molecules.
- Development of new antitumor therapy targeting GST-pi.
- Analysis and clinical application of the molecular mechanism in TRAIL-resistance.
- Molecular-genetic study on the analgesic effect of morphine to cancer pain and the occurrence of side effects.
- New theory for the creation of effective photosensitizer in photodynamic therapies for cancer.
- Efficient design of antisense oligonucleotide for molecular targeted therapies for cancer.
- Analysis of the molecular mechanism of 12p13 translocation leukemia.
- Diagnosis and treatment for cancer using labeled antibody.
- Analysis of action mechanism of differentiation inducer and examination of therapeutic effects.
- Investigation of new molecular targets involved in the canceration of cells and analysis of intracellular functions using libozyme library.
- Identification of molecular target for new terapy and diagnosis for sex hormone-dependent cancer andthe application.
- Development of a chemotherapeutics that are functional only in cancer cells, based on a completely new theory.
- Investigation of caspase-independent apoptosis derivatives and the molecular mechanism.
- Correlation analysis of the gene mutation polymorphisms in drug-metabolizing enzymes and the intensity of pharmacological reactions by anticancer agents.
- Gene expression of ganglioside GM3 synthetase and its biological functions.
- Molecular-biological research on the control of drug sensitivity and resistance.
- Research on resistance and sensitivity to antitumor agents using retrovirus gene transduction.
- Mechanism of telomere length control by tankyrase and suppression of cancer by telomerase inhibitor.
- Investigation of antitumor agents targeted to internal apoptosis inhibitor in cancer cells.
- Analysis on the resistance mechanism of apoptosis in chemotherapy and antibody therapy.
- Establishment of new cancer treatment by biologically fused nanoparticle which have radical developmental functions.
- Development and evaluation of a leukemia-selective molecular-targeted therapy.
- Preclinical examinations on antibody therapies and cancer.
- Study on new lung cancer therapy by RNAi targeting molecular characteristics of cancer cells.
- Development of new molecular targeted therapy for multiple-drug-resistant leukemia.
- Development of cancer treatment targeting HSCO and gankyrin that are excessively expressed in hepatic cancer.
- Suppression of cancer metastasis by cell-specific gene transfer therapy targeted for oxygen radical elimination enzyme.
- Gastrointestinal-carcinoma therapy by TCF decoy targeted at Wnt signal transcriptional activity.
- Development of anti-apoptosis drug targeted at permeability-increasing mechanism of mitochondrial membrane.
- Development of therapy targeted at the activating mutation of c-Kit and abnormal signal transduction of Flt3.
- New type of drugs to prevent cancer metastasis.
- Development of new oncolytic virus therapy targeted at telomerase activity, and analysis on its interaction with chemotherapy.
- Biological therapy of lung cancer, targeted at the metastasis and neovascularization-related molecules.
- Cancer therapy with synthetic hybrid ubiquitin coupling enzyme.
- Tailored cancer therapy targeted at the molecules related to drug sensitivity and neovascularization.
- Suppression by hypoxia of radiation-induced apoptosis signal, and hypoxia radiosensitizing agent. Focused on the expression of radiation induction TNF receptor.
- NF-.KAPPA.B-related radiosensitizing mechanism of radioresistant cancer cells.
- Mechanism of radiation induced apoptosis and estimation of the sensibility.
- Basic analysis of stress response mechanism upon the exposure to radiation and high temperature.
- DNA-PK, ATM transcriptional control analysis and the radiosensitivity regulation and prediction using the result.
- Signal transduction of the DNA-PK-dependent repair system in radiation-induced DNA damage, and application in the cancer radiotherapy.
- Analysis of the radioresistant signal transduction mechanism by IGF-I receptor.
- Development of therapy by radiation induced apoptosis.
- Involvement of poly (ADP ribose) metabolism in the body and cell level radiation response, and radiosensitization.
- Basic study on gene transfer and apoptosis induction for ultrasound cancer therapy.
- The role of the radiation induced Bystander effect by NO radical in radiotherapy.
- Development of the cancer treatment using the molecular chaperone induced by high temperature.
- Prediction of tumor hypoxic fraction and new therapy strategy for overcoming the radiotherapy resistance.
- Radiotherapy for intractable cancers using the recombination gene (Rad51).
- Basic research on neutron capture therapy for the X-ray-hyposensitive tumors.
- Radiosensitivity control mechanism of malignant lymphoma by oncogene products and antioncogene products.
- Basic study on radiation and high temperature cancer treatment combined with the molecular chaperone.
- Design of anticancerous nucleic acid derivatives, based on structure, sequence, and metabolic information.
- Search for new anticancer drug leading compounds targeted at growth factor REG.
- Elucidation of molecular markers for anticancerous substances found in new medicinal resources.
- Study on the cancer growth environment modifiers.
- Search for novel molecular targets for anticancer drugs among the new natural resources.
- Cancer suppression strategy with functional RNAs.
- Creation of medicinal leading molecules which inhibit cancer aggravation factors.
- Search for novel compounds that inhibit proliferation signal transduction.
- Search for anticancer agents targeted at apoptosis resistance of cancer cells.
- Overcoming the stress induced drug resistance targeted at proteosome protein degradation pathway.
- Analysis on the canceration signal transduction, and search for leading molecules for anticancer drugs.
- Action mechanism of antitumor agents obtained from natural resources, and the evaluation on disease models.
- Search for new target molecules for the cancer therapy by bioinformatics.
- Search for substances that suppress the malignant alteration to cancer cells.
- New search method for CTL immunoinducing anticancer agents, using natural melanoma mouse.
- Development of practical CXCR4 antagonist for antimetastasis drugs.
- Development of tailor-made anticancer drugs that correctly recognize DNA sequence.
- Development of telomerase inhibitor, based on the new conception "telomere knot" formation.
- Analysis on control of cancer invasion and metastasis by altering integrin sugar chain, and its molecular mechanism.
- Cancer therapy with novel interferon-like protein Limitin that causes less myelosuppression.
- Development of new canceration inducing agents targeted at cell cycle regulation.
- Development of small molecule cancer suppresser molecules and IL-6 inhibiting human antibodies with phage library.
- Significance of amplified MTH1 expression in human cancer cells, and the suprression of MTH1 expression and the function.
- Search for new molecular target in cancer cell response related to DNA disorders.
- Search for cell proliferation inhiviting agents targeted at signaling molecules for MAP kinase cascade.
- Anticancer drugs targeted at the zinc site on Ras farnesyl transferase.
- Development of new drugs to suppress proliferation, invasion, and metastasis of tumors.
- Morbidity of fat-related cancers in the people of Northern Europe and North Polar Region, and elucidation of environmental and host-related factors.
- Cancer epidemiology of Japanese immigrants in Brazil.
- Anthropological study on EB herpes virus-related cancer in Asia.
- Epidemiological cooperative research on the correlation between hepatolithiasis and intrahepatic cholangiocarcinoma in Taiwan.
- Host and environment factors associated to gastrointestinal cancers in 3 Southeast Asia Countries.
- Comparative epidemiological study on Gastrointestinal Cancer in Japan, China, and South Korea.
- Epidemiological analysis on the onset factors of nasal NK/T-cell lymphoma.
- Molecular epidemiological study on basal cell carcinoma of skin in East Kazakhstan State of Republic of Kazakhstan.
- Molecular epidemiological study on thyroid cancer in Chernobyl and the surrounding region.
- Onset factors for cancers in the Pacific Rim region.
- Cohort study on the correlation between the folic acid intake and the onset of colon and breast cancers.
- Cohort study on HPV infection and uterocervical oncogenesis.
- Epidemiological research on the environment and host factors of prostatic cancer.
- Study on living environment factors and serum estrogen for the breast cancer prevention.
- Large scale cohort study on the onset of colon cancer and fatality factors.
- Large-scale cohort study on serum components associated to the risk of prostatic cancer, urinary tract epithelial cancer, and renal cancer.
- Nested case control study on breast cancer among the victims of nuclear exposure, using the preserved serum samples.
- Case-control study on lifestyle factors associated to colon cancer.
- Epidemiological study on the risk factors of liver cancer based on the result data of large-scale cohort study.
- Development of gastric mucosal lesion and Helicobacter pylori. With a focus on the association with gastric cancer.
- Molecular epidemiological search for immune response to the target gene mutations in the cancer associated to the genetic instability.
- Case-control study on gene polymorphism associated to parasite-related biliary tract cancer in Thailand.
- Research on the risk of secondary development of primary-carcinoma arising from gastrointestinal cancer with a focus on the host and the environment-related factors.
- Molecular epidemiological technique to determine the pathology of familial endometrial carcinoma and genetic diagnosis.
- Cancer and prevention research on nuclear acceptor protein as the target molecule.
- The host/environmental interaction and cancer susceptibility based on metabolic enzyme gene polymorphism.
- Molecular epidemiological analysis and risk model of urinary tumors with a focus on prostatic cancer.
- Analysis on the gene polymorphism involved in the onset risk of urinary cancer and the sensitivity of cancer cell s to therapy.
- Mitochondrial genome analysis and comprehensive cancer risk management.
- Research on the individual differences and the host and environment factors associated to the expression of oncogenes.
- Molecular epidemiological research on the host factor associated to virus-related oncogenesis.
- Research on the molecules involved in the progression of gastrointestinal carcinoma, and the therapy and prognosis.
- Molecular epidemiological study on the types and progression of melanoma in Japanese population.
- Diagnosis and therapy of liver cancer with the use of biological markers. Clinical epidemiological study.
- Characteristics of lymphomas seen in Japanese population, with a focus on the Herpesvirus-related lymphomas.
- International research to create new taxonomy for T / NK cell lymphomas, with bioinformatics.
- Study on the biological prognostic factors associated to hematologic neoplasm.
- Search for the genes associated to esophageal cancer and gastric cancer with SAGE, and their significance in the onset, progression, and prognosis.
- Clinical epidemiology and grade of malignancy of squamous-epithelium cancer.
- Kinetic and performance analysis of hormone DHEA involved in the progression to myeloma from precancerous lesion BMG.
- Clinical epidemiological study on the expression of mucin gene, new adhesion factor, and prognosis in human cancer.
- Long-term followup study on the high risk group of ATL and the onset prevention.
- Regulation of the proliferation and the canceration of cells through the phosphorylation and the dephosphorylation of proteins.
- Regulation mechanisms for the proliferation and differentiation of cells by cancer-associated genes.
- Molecular mechanisms of signal transduction that regulates the proliferation, differentiation, and cycle of cells.
- Signal transduction in regulation of cell movement and cytoskeleton.
- Molecular mechanism in cell adhesion of epithelial cells and signaling of cell polarity.
- Molecular mechanism and abnormality in intercellular adhesion. Roles in cancerization, metastasis, and invasion.
- Identification and functional analysis of a new molecular group that regulates the dynamics of cancer cells.
- Molecular mechanism for generation, proliferation, and differentiation of hepatocytes.
- Study on interactions between epithelium and stroma in carcinogenesis.
- Molecular mechanism in regulation of cancerism.
- Differentiation of ES cells for understanding of formation mechanism of blood/vessel system and treatment of cells.
- Role of transcription factors in the cancerization of cells and the inhibition of cancerization.
- Gene expression network involved in cancer inhibition.
- Analysis of correlation between RB pathway and p53 pathway.
- Analysis on the regulation of cell proliferation by EGF family and the abnormal proliferation due to breakdown of the regulation.
- Molecular mechanism of TGF-beta signal and its abnormality in human cancer.
- Separation of intracellular signal molecule and analysis of the abnormality in human cancer.
- Regulation mechanism for tyrosine kinase signals.
- Development of method for cancer inhibition based on regulation of chromatin structure and its functions.
- Study on molecular mechanism of regulation in intranuclear receptor transcription.
- Analysis of the molecular mechanism and the physiological functions of apoptosis.
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