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J Antibiot

Beauveriolides, Specific Inhibitors of Lipid Droplet Formation in Mouse Macrophages, Produced by Beauveria sp. FO-6979.
Structure Elucidation of Fungal Beauveriolide III, a Novel Inhibitor of Lipid Droplet Formation in Mouse Macrophages.
Brasilicardin A, a New Terpenoid Antibiotic from Pathogenic Nocardia brasiliensis: Fermentation, Isolation and Biological Activity.
IC202A, a New Siderophore with Immunosuppressive Activity Produced by Streptoalloteichus sp. 1454-19. I. Taxonomy, Fermentation, Isolation and Biological Activity.
IC202A, a New Siderophore with Immunosuppressive Activity Produced by Streptoalloteichus sp. 1454-19. II. Physico-chemical Properties and Structure Elucidation.
Zelkovamycin, a New Cyclic Peptide Antibiotic from Streptomyces sp. K96-0670. I. Production, Isolation and Biological Properties.
Zelkovamycin, a New Cyclic Peptide Antibiotic from Streptomyces sp. K96-0670. II. Structure Elucidation.
Growth and Production Kinetics of a Teicoplanin Producing Strain of Actinoplanes teichomyceticus.
Immunosuppressant Deoxyspergualin-induced Inhibition of Cell Proliferation is Accompanied with an Enhanced Reduction of Tetrazolium Salt.
Studies on Time-Kill Kinetics of Different Classes of Antibiotics Against Veterinary Pathogenic Bacteria Including Pasteurella, Actinobacillus and Escherichia coli.
Isolation and Structure of a New Antibiotic Viridomycin F Produced by Streptomyces sp. K96-0188.
Inhibitory Effect of Antimicrobial Agents on Alginate Production in Pseudomonas aeruginosa.
New Derivatives of Tylosin. IV. Dihydro and Tetrahydro Desmycosin Oximes.
Effects of Erythromycin and Its Derivatives on Interleukin-8 Release by Human Bronchial Epithelial Cell Line BEAS-2B Cells.
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Phosphatoquinones A and B, Novel Tyrosine Phosphatase Inhibitors Produced by Streptomyces sp.
Purification and Characterization of 2-Deoxy-scyllo-inosose Synthase Derived from Bacillus circulans. A Crucial Carbocyclization Enzyme in the Biosynthesis of 2-Deoxystreptamine-containing Aminoglycoside Antibiotics.
Isolation and Characterisation of a Prenylated p-Terphenyl Metabolite of Aspergillus candidus Possessing Potent and Selective Cytotoxic Activity; Studies on Mechanism of Action.
Biosynthesis of Polyketomycin Produced by Streptomyces diastatochromogenes Tue 6028.
Production of Nikkomycins Bx and Bz by Mutasynthesis with Genetically Engineered Streptomyces tendae TUE901.
Bioconversion of Milbemycin-related Compounds: Biosynthetic Pathway of Milbemycins.
Biosynthesis of the Pyrroindomycins by Streptomyces rugosporus LL-42D005; Characterization of Nutrient Requirements.
Time and Concentration Dependent Influence of Dirithromycin on Neutrophils Oxidative Burst.
(-)-Phenylahistin Arrests Cells in Mitosis by Inhibiting Tubulin Polymerization.
Structure-activity Relationships of Carbapenems to the Antagonism of the Antipseudomonal Activity of Other .BETA.-Lactam Agents and to the .BETA.-Lactamase Inducibility in Pseudomonas aeruginosa: Effects of 1.BETA.-Methyl Group and C-2 Side Chain.
First Total Synthesis of N-4909 and Its Diastereomer; A Stimulant of Apolipoprotein E Secretion in Human Hepatoma Hep G2 Cells.
Structure-specific Inhibition of Cholesteryl Ester Transfer Protein by Azaphilones.
11-Keto-9(E),12(E)-octadecadienoic Acid, a Novel Fatty Acid that Enhances Fibrinolytic Activity of Endothelial Cells.
SNA-4606-1, a New Member of Elaiophylins with Enzyme Inhibition Activity Against Testosterone 5.ALPHA.-Reductase.
BE-40665D, a New Antibacterial Antibiotic Produced by an Actinoplanes sp.
Korormicin, an Antibiotic Specific for Gram-negative Marine Bacteria, Strongly Inhibits the Respiratory Chain-linked Na+-Translocating NADH: Quinone Reductase from the Marine Vibrio alginolyticus.
In Vitro Anti-methicillin-resistant Staphylococcus aureus Activity Found in Extracts of Marine Algae Indigenous to the Coastline of Japan.
Structural Elucidation of a Novel Erythromycin, 13-Cyclopentyl-13-desethyl-erythromycin B, from a Recombinant Saccharopolyspora erythraea Strain, NRRL 2338 pIG/1.
Absolute Stereochemistry Determination of 16-Methyloxazolomycin Produced by a Streptomyces sp.
Adxanthromycin: A New Inhibitor of ICAM-1/LFA-1 Mediated Cell Adhesion from Streptomyces sp. NA-148.
Production of Erythromycin E by Pathogenic Nocardia brasiliensis.
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Asterriquinones Produced by Aspergillus candidus Inhibit Binding of the Grb-2 Adapter to Phosphorylated EGF Receptor Tyrosine Kinase.
A Novel Fungal Metabolite NG-061 Enhances and Mimics Neurotrophic Effect of Nerve Growth Factor(NGF) on Neurite Outgrowth in PC12 Cells.
Structure of NG-061, a Novel Potentiator of Nerve Growth Factor(NGF) Isolated from Penicillium minioluteum F-4627.
RP-1551s, a Family of Azaphilones Produced by Penicillium sp., Inhibit the Binding of PDGF to the Extracellular Domain of Its Receptor.
Glucolipsin A and B, Two New Glucokinase Activators Produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii.
Novel Naphthoquinones from a Streptomyces sp.
Gilvusmycin, a New Antitumor Antibiotic Related to CC-1065.
Lactonamycin, a New Antimicrobial Antibiotic Produced by Streptomyces rishiriensis MJ773-88K4. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.
Lactonamycin, a New Antimicrobial Antibiotic Produced by Streptomyces rishiriensis MJ773-88K4. II. Structure Determination.
New Types of Liposidomycins Produced by Streptomyces that Inhibit Bacterial Peptidoglycan Synthesis Structure Elucidation of Fatty Acid Components by Tandem Mass Spectrometry.
Molecular Analysis of tlrB, an Antibiotic-resistance Gene from Tylosin-producing Streptomyces fradiae, and Discovery of a Novel Resistance Mechanism.
Inhibition of Nitric Oxide Synthase Induction by 15-Deoxyspergualin in a Cultured Macrophage Cell Line, J744A.1 Activated with IFN-.GAMMA. and LPS.
Mulundocandin, an Echinocandin-like Lipopeptide Antifungal Agent: Biological Activities In Vitro.
Aspirochlorine: A Highly Selective and Potent Inhibitor of Fungal Protein Synthesis.
Chemical Modification of Antibiotic Eremomycin at the Asparagine Side Chain.
Kitamycins, New Antimycin Antibiotics Produced by Streptomyces sp.
De-N-methylpamamycin-593A and B, New Pamamycin Derivatives Isolated from Streptomyces alboniger.
9-Hydroxyoudemansin A, a Novel Antifungal (E)-.BETA.-Methoxyacrylate from a Mycena species.
Inactivation of Fusidic Acid by Pathogenic Nocardia.
Skeletal Structure of Neocopiamycin B from Streptomyces hygroscopicus var. crystallogenes.
Synthesis of 1-Monoglycerides Having C11-20 Branched Chain Fatty Acids and Their Hemolysis Effects.
A Facile Synthesis of D-Galactose-type Gem-Diamine 1-N-Iminosugar: A New Family of Galactosidase Inhibitor.
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Lichenysins G, a Novel Family of Lipopeptide Biosurfactants from Bacillus licheniformis IM 1307: Production, Isolation and Structural Evaluation by NMR and Mass Spectrometry.
Feglymycin, a Novel Inhibitor of the Replication of the Human Immunodeficiency Virus. Fermentation, Isolation and Structure Elucidation.
Structure Elucidation of Sch 20562, a Glucosidic Cyclic Dehydropeptide Lactone. The Major Component of W-10 Antifungal Antibiotic.
Structure Elucidation of Sch 20561, a Cyclic Dehydropeptide Lactone. A Major Component of W-10 Antifungal Antibiotic.
A New Enzyme, Edeine B1 Amidinohydrolase, from Bacillus brevis TT02-8. Purification and Determination of the N-terminal Amino Acid Sequence.
Diazaphilonic Acid, a New Azaphilone with Telomerase Inhibitory Activity.
C-1027 Enediyne Chromophore: Presence of Another Active Form and Its Chemical Structure.
Synthesis of an N-Methyl-D-aspartate Receptor Antagonist, ES-242-5, and Its Analogs.
Inhibition of Angiogenesis by a New Isocoumarin, NM-3.
Screening of Microbial Products Modifying the Action of Leptin (Obese Gene Product) by a Biosensor.
Absolute and Atropisomeric Structure of ES-242s, N-Methyl-D-aspartate Receptor Antagonists.
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High-mannose Type Oligosaccharide-dependent Apoptosis in U937 Cells Induced by Pradimicin, a Mannose-binding Antibiotic.
Involvement of Ca2+ Ion and Reactive Oxygen Species as a Mediator in Pradimicin-induced Apoptosis.
Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520. III. Inhibitory Properties.
Sanglifehrins A, B, C and D, Novel Cyclophilin-binding Compounds Isolated from Streptomyces sp. A92-308110. I. Taxonomy, Fermentation, Isolation and Biological Activity.
Sanglifehrins A, B, C and D, Novel Cyclophilin-binding Compounds Isolated from Streptomyces sp. A92-308110. II. Structure Elucidation, Stereochemistry and Physico-chemical Properties.
UK-2A, B, C and D, Novel Antifungal Antibiotics from Streptomyces sp. 517-02. IV. Comparative Studies of UK-2A with Antimycin A3 on Cytotoxic Activity and Reactive Oxygen Species Generation in LLC-PK1 Cells.
Effect of Thiazinotrienomycin B, an Ansamycin Antibiotic, on the Function of Epidermal Growth Factor Receptor in Human Stomach TumorCells.
AS-924, a Novel Bifunctional Prodrug of Ceftioxime.
New Members of the Macrocphelides from Microsphaeropsis sp. FO-5050 IV.
Novel Antibiotics Pyrisulfoxin A and B Produced by Streptomyces californicus.
A Novel Screen for the Detection of Chitin Acting Antifungal Compounds.
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Scyphostatin, a Neutral Sphingomyelinase Inhibitor from a Discomycete, Trichopeziza mollissima: Taxonomy of the Producing Organism, Fermentation, Isolation, and Physico-chemical roperties.
Biological Activities of Scyphostatin, a Neutral Sphingomyelinase Inhibitor from a Discomycete, Trichopeziza mollisima.
WF14861, a New Cathepsins B and L Inhibitor Produced by Colletotrichum sp. I. Taxonomy, Production, Purification and Structure lucidation.
WF14861, a New Cathepsins B and L Inhibitor Produced by Colletotrichum sp. II. Biological Properties.
Conagenin Derived from Streptomyces roseosporus Enhances Macrophag Functions.
Efficacy of Antibacterial Drugs in Mice with Complex Infection by Candida albicans and Escherichia coli.
Molecular Cloning of the Gene for the Key Carbocycle-forming Enzyme in the Biosynthesis of 2-Deoxystreptamine-containing Aminocyclitol Antibiotics and Its Comparison with Dehydroquinate Synthase.
Alutenusin, a Specific Neutral Sphingomyelinase Inhibitor, Produced by Penicillium sp. FO-7436.
TMC-169, a New Antibiotic of the Aspochalasin Group Produced by Aspergillus flavipes.
Cinnatriacetins A and B, New Antibacterial Triacetylene Derivatives from the Fruiting Bodies of Fistulina hepatica.
Novel Nikkomycins Lx and Lz Produced by Genetically Engineered Streptomyces tendae Tue901.
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TMC-66, a New Endothelin Converting Enzyme Inhibitor Produced by Streptomyces sp. A5008.
Antiviral and Hemolytic Activities of Surfactin Isoforms and Their Methyl Ester Derivatives.
Bioconversion of Milbemycin-related Compounds. Isolation and Utilization of Non-producer, Strain RNBC-5-51.
Mode of Action of Anhydrofulvic Acid against Candida utilis ATCC 42402 under Acidi Condition.
Cineromycins, .GAMMA.-Butyrolactones and Ansamycins by Analysis of the Secondary Metabolite Pattern Created by a Single Strain of Strepomycest.
Convergent Syntheses of Oral THF 1.BETA.-Methylcarbapenems.
In Vitro Antibacterial Activity of FK041, a New Orally Active Cephalosporin.
In Vivo Antibacterial Activity of FK041, a New Orally Active Cephalosporin.
Isolation and Structural Elucidation of New Peptaibols, Bergofungins B, C and D, from Emericellopsis donezkii HKI 0059.
Macquarimicin A Inhibits Membrane-bound Neutral Sphingomyelinase from Rat Brain.
FK463, a Novel Water-soluble Echinocandin Lipopeptide. Synthesis and Antifungal Activity.
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Roselipins, Inhibitors of Diacylglycerol Acyltransferase, Produced by Gliocladium roseum KF-1040.
Rhodopeptins (Mer-N1033), Novel Cyclic Tetrapeptides with Antifungal Activity from Rhodococcus sp. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.
Rhodopeptins, Novel Cyclic Tetrapeptides with Antifungal Activities from Rhodococcus sp. II. Structure Elucidation.
Rhodopeptins, Novel Cyclic Tetrapeptides with Antifungal Activities from Rhodococcus sp. III. Synthetic Study of Rhodopeptins.
Melithiazols, New .BETA.-Methoxyacrylate Inhibitors of the Respiratory Chain Isolated from Myxobacteria. Production, Isolation, Physico-chemical and Biological Properties.
Ala(0)-actagardine, a New Lantibiotic from Cultures of Actinoplanes liguriae ATCC 31048.
Production of 6-Deoxy-13-cyclopropyl-Erythromycin B by Saccharopolyspora erythraea NRRL 18643.
UK-2A, B, C and D, Novel Antifungal Antibiotics from Streptomyces sp. 517-02. V. Inhibition Mechanism of Bovine Heart Mitochondrial Cytochrome bc1 by the Novel Antibiotic UK-2A.
Novel Cyclopentanone Derivatives Pentenocins A and B, with Interleukin-1 .BETA. Converting Enzyme Inhibitory Activity, Produced by Trichoderma hamatum FO-6903.
Phenazostatin C, a New Diphenazine with Neuronal Cell Protecting Activity from Streptomyces sp.
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IC202B and C, New Siderophores with Immunosuppressive Activity Produced by Streptoalloteichus sp. 1454-19.
Decatromicins A and B, New Antibiotics Produced by Actinomadura sp. MK73-NF4. I. Taxonomy, Isolation, Physico-chemical Properties and Biological Activities.
Decatromicins A and B, New Antibiotics Produced by Actinomadura sp. MK73-NF4. II. Structure Determination.
Inhibition of Plasminogen Activator Inhibitor-1 by 11-Keto-9(E),12(E)-octadecadienoic Acid, a Novel Fatty Acid Produced by Trichoderma sp.
The Decrease of Cytochrome c Oxidase Activity by 15-Deoxyspergualin Results in Enhancement of XTT Reduction in Cultured Cells.
Enzymatic 1-N-Acetylation of Paromomycin by an Actinomycete Strain #8 with Multiple Aminoglycoside Resistance and Paromomycin Sensitivity.
Structure Elucidation of Roselipins, Inhibitors of Diacylglycerol Acyltransferase Produced by Gliocladium roseum KF-1040.
F-11334s, New Inhibitors of Membrane-bound Neutral Sphingomyelinase.
Preparation and In Vitro Antibacterial Activity of 6-O-Methylerythromycin D.
Solid-Phase Synthesis of Cyclooctadepsipeptide N-4909 Using a Cyclization-Cleavage Method with Oxime Resin.
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Phenochalasins, Inhibitors of Lipid Droplet Formation in Mouse Macrophages, Produced by Phomopsis sp. FT-0211.
Structure Elucidation of Fungal Phenochalasins, Novel Inhibitors of Lipid Droplet Formation in Mouse Macrophages.
A Novel (6S)-4,6-Dimethyldodeca-2E,4E-dienoyl Ester of Phomalactone and Related .ALPHA.-Pyrone Esters from a Phomopsis sp. with Cytokine Production Inhibitory Activity.
Vinylamycin, a New Depsipeptide Antibiotic, from Streptomyces sp.
Heme-dependent Radical Generation. Possible Involvement in Antimalarial Action of Non-peroxide Microbial Metabolites, Nanaomycin A and Radicicol.
Role of Aminoglycoside 6'-Acetyltransferase in a Novel Multiple Aminoglycoside Resistance of an Actinomycete Strain #8. Inactivation of Aminoglycosides with 6'-Amino Group Except Arbekacin and Neomycin.
A Mammalian Vector Carrying the Bleomycin N-Acetyltransferase Gene from Bleomycin-producing Streptomyces verticillus as a Selective Marker.
Synthesis and Biological Evaluation of New Oral Carbapenems with 1-Methyl-5-oxopyrrolidin-3-ylthio Moiety.
Synthesis and Antibacterial Activities of Novel 12-D-Methylerythromycin A Derivatives.
Production, Isolation and Biological Properties of TMC-120A, B and C, Novel Inhibitors of Eosinophil Survival from Aspergillus ustus TC 1118.
Isolation and Characterization of Gibbestatin B, an Inhibitor of Gibberellin-induced Expression of .ALPHA.-Amylase, and Gibbestatin C from Streptomycetaes.
Indocarbazostatin, a Novel Inhibitor of NGF-induced Neurite Outgrowth from Rat Pheochromocytoma PC12 Cells.
Studies on the Biosynthesis of Bialaphos (SF-1293). 18. 2-Phosphinomethylmalic Acid Synthase. A Descendant of (R)-Citrate Synthase?
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Biounolecular-chemical Screening. A Novel Screening Approach for the Discovery of Biologically Active Secondary Metabolites. I. Screening Strategy and Validation.
Bionrolecular-chemical Screening. A Novel Screening Approach for the Discovery of Biologically Active Secondary Metabolites. II. Application Studies with Pure Metabolites.
Stresgenin B, an Inhibitor of Heat-induced Heat Shock Protein Gene Expression, Produced by Streptomyces sp. A-9.
EM2487, a Novel Anti-HIV-1 Antibiotic, Produced by Streptomyces sp. Mer-2487. Taxonomy, Fermentation, Biological Properties, Isolation and Structure Elucidation.
Agrochelin, a New Cytotoxic Antibiotic from a Marine Agrobacterium Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity.
Memnobotrins and Memnoconols. Novel Metabolites from Memnoniella echinata.
Tylopeptins A and B, New Antibiotic Peptides from Tylopilus neofelleus.
In Vitro Microbiological Characterization of Novel Cyclic Homopentapeptides, CP-101,680 and CP-163,234, for Animal Health Use.
Effective Production of Dehydro Cyclic Dipeptide Albonoursin Exhibiting Pronuclear Fusion Inhibitory Activity. I. Taxonomy and Fermentation.
Structures of Flagranones A, B and C, Cyclohexenoxide Antibiotics from the Nematode-trapping Fungus Duddingtonia flagrans.
Semisynthetic Derivatives of Madurahydroxylactone and Their Antibacterial Activities.
Inhibition of Cholesteryl Ester Transfer Protein by Fungal Metabolites, L681,512.
UCT1072s, New Antitumor Antibiotics with Topoisomerase II Mediated DNA Cleavage Activity, from Aspergillus sp.
Structural Modification of the Lincolnycin Antibiotic.
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TMC-86A, B and TMC-96, New Proteasome Inhibitors from Streptomyces sp. TC 1084 and Saccharothrix sp. TC 1094. I. Taxonomy, Fermentation, Isolation, and Biological Activities.
Production of a Family of Kinase-inhibiting Lactones from Fungal.
Resorcylic Acid Lactones. Naturally Occurring Potent and Sclective Inbibitors.
Funalenone, a Novel Collagenase Inbibitor Produced by Aspergillus niger.
Ferroverdins, Inhibitors of Cholesteryl Ester Transfer Protein Produccd by Streptomyces sp. WK-5344. I. Production, Isolation and Biological Properties.
Ferroverdins, Inhibitors of Cholesteryl Ester Transfer Protein Produced by Streptomyces sp. WK-5344. II. Structure Elucidation.
TMC-171A, B, C and TMC-154, Novel Polyketide Antibiotics Produced by Gliocledjum sp. TC 1304 and TC 1282.
Biomolecular-chemical Screening. A Novel Screening Approach for the Diseovery of Biologically Active Seeondary Metabolites. III. New DNA-binding Metabolites.
Presence of Genes for .BETA.-Lactamases of Two Different Classes on a Single Plasmid from a Clinical Isolate of Serrtia marcescens.
Synthcsis and Properties of the Pyrrole Analogs of cnoramphenicol.
Tylosin Derivatives. V. Electrochemical Opening of Oxirane Ring.
The Total Synthesis and Absolute Structure of Antifungal Antibiotics (-)-PF 1163A and B.
Synthesis and Biological Properties of a Novel Cephalosporin FR86521 Having Potent Activity Against Methicillin-resistant Staphylococcus aureus (MRSA).