Science Links Japan | Uehara Kinen Seimei Kagaku Zaidan Kenkyu Hokokushu

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Uehara Kinen Seimei Kagaku Zaidan Kenkyu Hokokushu

Optimization of percutaneous absorption system by modification of dosage form using the artificial neural network method.
Molecular design of artificial gene carrier based on the intracellular dynamic control.
Synthesis and pharmacological application of the metal complexation type artificial nucleoside.
Synthesis and function exploratory research of nitrogen containing piloting molecule for the basic research of development of new drugs.
New tandem type ring enlargement reaction the application to development of the cyclization reaction and the Calcitriol-OSW-1 hybrid synthesis.
The creation of the non-natural type natural product skeleton by the evolution engineering technique.
The elucidation of the interaction of carbohydrate chain molecule and biomolecule which made the glycoconjugate to be a material.
Control mechanism of the drug transporter by sigma receptor.
The research of DNA polymerase specific inhibitor.
Efficient synthesis chemical development of the catalytic asymmetry Baylis-Hillman reaction.
Development of the new asymmetric cyclization reaction between 1,3 - diene and carbonyl group and application of the polycyclic compound to catalytic asymmetric synthesis by the Ni catalyst.
Synthesis and activity of the pyrrolinone chemical compound.
The development of high sensitivity of biologically active agent using the capillary electricity chromatography method and high-speed separation analysis method.
Effect of Japanese and Chinese drug on cerebral blood flow and neurologic manifestation in patient with asymptomatic cerebrovascular disorder.
Elucidation of the role of myocardial magnesium in the sudden death during exercise.
Magnesium and potassium deficiency and sudden death and sex difference. Tracking by stable isotope.
Effect of nutrition and heredity on hyperlipidemia and arteriosclerosis. Research using Apo E defect mouse with various genetic background.
Change of circulatory function and maximal oxygen uptake by the age.
Research on the expression of main gene associated with physical fitness level in the human skeletal muscle.
High sensitive analysis of volatile drug and toxicant in the body fluid by cryogenic oven trapping.
Elucidation of the transmission mechanism of endocrine disrupting chemicals ( environmental hormone ) in placental barrier.
Demonstration of new cervical coppression using myoglobin contained in thyroid gland as an index.
Relation between vitamin D in the meal using dupulicated food, human blood 25-hydoxy vitamin D concentration, and bone density.
Development of the transgenic mouse with less intracellular adiposity and effect of the lifestyle on these animals. Analysis of visceral obesity.
Probiotic lactic bacteria and "biophylactic food".
The control by the localization of tumor suppression protein p53 inductivity phosphatase Wip1 in the cell cycle.
Cell function control by the modification of caveola.
Research on the molecular mechanism regulating the cardiac contractility.
Left-right asymmetry of the heart and Tbx5 gene.
The analysis of asymmetry control of expression mechanism of the gene which is related to the left-right asymmetry decision of the body.
The molecular-biological research on function and expression of new transcription factor RLG-1 with the Ring-H2finger motif.
Analysis of the intranuclear transcriptional control system as a cause of the individual difference of drug metabolism and its prediction.
Physiological significance of 2-arachidonyl glycerol.
Glutamic acid as a risk factor of neuron death in centeral degenerative disease and search of the intrinsic protective factor regulating the cytotoxicity of nitrogen monoxide and elucidation of its action mechanism.
Analysis of amyloid precursor secretase family in Alzheimer disease.
Molecular biological and cytobiological research of the human blood coagulation factor XIII.
Research on role of low molecular weight G protein Rho family in the central neuron networking and participation in the neurologic disease.
The regulation mechanism of antibody-forming cell gene homologous recombination.
The control of the reproductive performance by hormone and pheromone.
Morphogenesis of mammal adrenal cortex and molecular mechanism of cell differentiation.
Examination of the in vivo effect of calpain inhibitor E-64-d administration in the model mouse with congenital immune deficiency disease, Chediak-Higashi syndrome.
Escape mechanism of HIV-1 from CTL.
Elucidation of pathogen recognitive mechanism in the infectious immunity.
Mechanism of pit formation by the hemoclastic toxin of the staphylococcus.
Two-sided action of the inhibitor of chemokine receptor.
Molecular medical research on the oncogenesis mechanism by variant keratinocyte growth factor receptor (KGFR) concerning generation and progress of the parathyroid adenoma.
The role in generation and carcinogenesis of the new DNA methylation enzyme family of Mammalia.
Function of the LIM kinase in cell movement, especially in cancer invasion and metastasis.
Plasticity of the neuronal circuit for braille discrimination.
Integrated and concurrency control mechanism and high-order function of Primates walking movement.
The elucidation of the molecular mechanism of polarity and axon formation of nerve cell by CRMP-2.
Design, synthesis and organism application of living cell fluorescence probe.
Morphological retrieval of the factor concerning the inhibitory neural network formation and supposition of the formation mechanism.
Cell cycle regulation of human DNA replication.
The analysis of meiosis control mechanism in fission yeast.
The analysis of the transcriptional control mechanism of the TGF-.BETA. signal.
The application of the nerve cell to differentiation, cell proliferation, plastic control mechanism and neurodegenerative disease therapy by the TGF-.BETA. group cell growth factor.
The elucidation of the target protein recognition mechanism ( the targeting mechanism ) with the aim of the development of protein kinase C molecular species specific inhibitor.
The elucidation of the physiological function of the cytokine inductivity SH2(Srchomology2) protein CIS and JAB family.
The functional analysis of tyrosine kinase Syk in vascular endothelial cell.
The exchange mechanism of information of pheromone in the periphery, and the mechanism of the learning memory of the smell in the center.
The analysis of the leukotriene B4 receptor.
The research on growth factor activity regulation by the Kunitz type serine protease inhibitor on especially, Hepatocytegrowthfactor (HGF), HGFactivator (HGFA) and the it's inhibitor (HAI).
MAP kinase BMK1 controls the TNF-.ALPHA. production by the macrophage.
Rho and neurological function.
Elucidation of the cell kinetics in the process of wound healing.
Elucidation of the molecular mechanism of migration control of nerve cell.
The elucidation of in vivo metabolism mechanism and endocrine disturbance mechanism of "endocrine disturbance substance" ( environmental hormone ) by the sulfuric acid transferase.
The molecule-physiological research of cytophylaxis chlorine ion channel as a target of nitrogen monoxide and cyclic GMP route.
The research on the function of the anion channel which contributes to the minimal cerebral vessel tonus.
The analysis of vesicle transport regulation mechanism by the protein with coiled and coil structure.
Mechanism of differential inhibition in myelin formation cell and differential induction by derepression.
The analysis of the gene cluster expressed in the testis specific using the insect.
The role of HSF system in the developmental process.
The elucidation of NK cell, NKT cell activation molecule using the retrovirus cDNA library.
Regulation mechanism of eosinophil production by transcription factor RFX.
The analysis of the property of a mucosa immunity system derivation memory B lymphocyte.
The molecular mechanism of diversity acquirement of immunoglobulin gene.
Analysis of inflammation control mechanism induced by antigen specific activation of human .GAMMA..DELTA.T cell. Especially on inflammation control mechanism of .GAMMA..DELTA.T cell in the synovial membrane of rheumatoid arthritis and bronchial lavage cell of asthma lung.
Conversion from the nucleus of homeobox protein Six to the cytoplasm and cell cycle control and canceration mechanism.
Search of the ganglioneuroblastoma associated tumor supressor gene on the short arm of chromosome 1 (1p36).
The participation of the tumor supressor gene (EXT:hereditarymultipleexostoses) family in the heparan sulfate biosynthesis in the nematode.
Basic research of cancer cell elimination using the phagocytosis.
Developement of bionic baroreflex system against central baroreflex failure.
Ergosterol is necessary for the step of the priming of the membrane fusion.
The role of GRASS gene in the Activin/Nodal signaling pathway.
The molecular genetic analysis of the neural network formation.
Generation and signaling through FRS2 in the nerve.
Biotaxis between blood vascular system and nervous system.
The functional analysis of glutamate receptor extacellular region as a molecule with synaptic plasticity.
Apoptosis and disease by the structual aberration of protein.
Denaturated protein recognition mechanism of GroEL.
The identification of the activating factor of the I-.KAPPA.B kinase which is an indispensable factor in TNF-.ALPHA. and IL-1 intracellular signal transduction route.
The analysis of the gene abnormality correlating with the prognosis of mammary cancer.
The function of the myosin phosphatase in the smooth muscle tonus control.
Research on cardiovascular disoder in Kawasaki disease.
Molecular mechanism in the primary lesion formation of the arteriosclerosis.
Elucidation of the pathophysiology of hypertension from the abnormality of cell membrane function and Ca metabolic mechanism.
Establishment of genetic databases of Japanese population using DNA chip technology and large-scale epidemiological population.
Functional analysis of Reg in proliferation of gastric mucosa using Reg transgenic mouse.
Treatment of the intractable liver disease by functional regulation of hepatic sinusoidal endothelial cell using gene engineering.
Research on pathogenic diagnosis and treatment of the brain white matter dementia.
Cloning of transporter of the uric acid.
The involvement of insulin receptor substrate (IRS-1,-2) for bone metabolic disorder. Analysis of genomic SNP in patients and knockout mice.
Genetic factor and genome imprinting in osteoporosis.
Elucidation of growth mechanism of endothelial cell through the crosstalk with tunica medial smooth muscle cell.
Application of the absorbable material to heart and vascular surgery.
Molecular-biological research of portal hemodynamics in hemorrhage of esophagus varix.
Fetal extracorporeal circulation and vasoactive mediator.
Gene therapy for cancer using telomerase.
Elucidation of cytogenetic characteristics and interstitium dependent proliferation and differentiation mechanism of leukemia cell and its clinical application in elderly leukemia.
Elucidation of extracellular matrix stabilization factor regulatory mechanism and development of the new therapy for acute coronary syndrome.
Elucidation of the genetic basis of the Multiple risk factor syndrome using model animal.
Molecular-genetic examination on the genetic factor in coronary spastic angina.
Gi protein gene therapy for the endothelial nitrogen monoxide production failure in the arteriosclerosis.
Research on pathogenesis of alcoholic chronic pancreatitis from the viewpoint of the pancreatic duct cell.
Physiological significance of signal transduction through serotonin receptor in neuronal circuit regulating the emotion, pathogenesis of its failure, and the action mechanism in pharmacotherapy of affective disorder.
Application of estrogen receptor and its response gene to biofunction and drug discovery.
Effect of fibroblast reduction by gene manipulation for the progress of renal insufficiency in human immunodeficiency virus associated nephropathy.
Molecule medical research on the clinical significance of the obesity gene products ( leptin ) in the lifestyle related disease.
Elucidation of in vivo direct action of leptin to peripheral organ using the transgenic mouse.
Analysis of pathogenesis of diabetes mellitus based on HNF transcription factor network.
Research of transcription factor concerning the fibrillation of scleroderma.
Genetic analysis of model mouse with osteoarthrosis.
Molecular cytopathological analysis of barrier dysfunction in atopic dermatitis. Examination using spontaneous atopic dermatitis mouse ( NC/Nga mouse ).
Control of IgE production from human peripheral lymphocyte by synthetic single stranded DNA.
Detection of Helicobacter pylori from feces and examination of infection route in children by genetic analysis.
Elucidation of apoptosis resistance in gastric cancer and possibility of gene therapy by transfer of the apoptosis-inducing gene.
Approach to development of new therapy for the intractable solid tumor.Tumor cell death induction by synergic action of tumor supressor gene re-introduction and chemotherapy with inhibitor of DNA synthesis/irradiation.
Examination of gastric cancer generation in animal infected with Helicobacter pylori infection animal from the viewpoint of the host. Proliferation and disproportion of the cell death and carcinogenesis by Helicobacter pylori.
Establishment of in vitro synthetic system of serotype specific polysaccharides antigen and development of vaccines for periodontal disease using obtained polysaccharides.
Statins facilitate the fibrinolytic system in the atherosclerotic lesion.
Analysis of differentiation and proliferation mechanism of hemopoietic cell.
Chemical modification of transcription factor by reactive nitrogen oxides and regulatory mechanism of MMP expression.
Diagnosis of pancreatic lesion by aspiration using Mechanical secter type endoscopic ultrasonography.Prospective comparison with Convex type endoscopic ultrasonography.
Identification of SCA10 gene and analysis of pathogenetic mechanism.
Role of Lipotransin in the lipid metabolism.
New synthetic oleic acid, CDDO, accelerates the apoptosis of the human osteosarcoma cell in caspase-8 dependent manner.
Evaluation of blood flow waveform in internal thoracic artery after coronary artery bypass grafting by apex Doppler echocardiography.
Retina specific expression of new homoeobox gene (RINX). Analysis of regulatory mechanism of expression of the visual pigment gene.
Immunologic tolerance induction of anti.ALPHA.-Gal natural antibody producing B cell and conquest of the hyperacute rejection in the heterogenous organ transplantation. The control of natural antibody in the heterogenous organ transplantation.
Present state of assistant artificial heart as a bridge to heart transplantation.
Inhalational anesthetic and GABA-A receptor.