Science Links Japan | Uehara Kinen Seimei Kagaku Zaidan Kenkyu Hokokushu

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Uehara Kinen Seimei Kagaku Zaidan Kenkyu Hokokushu

Prodrug design based on the molecular recognition of the carboxylesterase.
Combinantial approach to the immobilization asymmetric catalyst which functions in the perfect water system.
Efficiency improvement of superacid catalyst aromatic electrophilic reaction using supercritical fluid.
Practical synthesis of the heterocyclic compound.
Scientific and medical research of new immunosuppressive agent SQAG9 which is equal to FK-506.
Development research of the molecule who recognizes tertiary structure of the protein.
Research of Shosoin drug "Jikathu" and relation gelsemium genus plant alkaloid.
Elucidation of the macrolide antibiotic of anti-inflammatory and immunopotentiative action and the application.
Establishment of the quantitative prediction method of lethality electrocardiographical side effect by the non-cycling system drug.
Development research of brain directionality drug delivery method using the Megalin mediating endocytosis.
Structural biology research of the self secretory motion factor which aimed at development of metastasis control medicine.
An N-Ar Axially Chiral Mimetic. A New Approach to Ligand Design for Asymmetric Catalysis.
Development of functional group and stereoselective activation catalyst of polyol which makes the combination of a Lewis acid - base to be a basis.
Total synthesis of antiinflammatory activity marine natural product.
Research of intractable infectious disease conquest by the biological active substance cluster.
Anti-siguatoxin antibody preparation and vaccine development.
Search and development of antitumor material of the ocean symbiosis algae derivation.
Metastasis control effect of Juzen-taiho-to in the renal cell carcinoma.
Regulation factor of oxyecoia intake dynamic phase in the high-intense motion repeatedly.
Investigation and research on extent and pathologic finding of the AIDS virus infection in social medicine like in Asia.
Contribution system and market penetration in the foreign-capital medical supply enterprise and international comparison and research of the advance strategy in the inside.
Development of the removal method of dioxin and environment hormone accumulated in human body.
Research on nutritional factor and oxidation-ee activity of the LDL.
Adjustment of the bone remodeling by the ascorbic acid.
Research on the control of anomalous animal behaviour by the nutrient.
The treatment of the uveitis by the chinese medicine.
Physiological verification of new permanence training method by highland ( low-pressure hypoxia ) hot environment concurrent exposure.
Research on muscle damage by extensibility muscular activity and characteristic change of the musculotendon complex.
The research for elucidation and protective measure establishment of Steven-Johnson syndrome occurrence mechanism in the trichloroethylene use workshop. From the viewpoint of cause and disease state investigation of the chemical substance hypersensitivity.
Possibility of the Parkinson disease induction of the paraquat.
Research of arteriosclerosis mechanism of pathogenesis of the oxidation sterol.
Human LAT1 gene expression regulation elucidation of mechanism and knockout mouse preparation.
Food allergy prevention and food design which intends the treatment function and the basis analysis.
Existence of caveolin in gastric-acid secretion cell.
Research on enormous polynucleated cell production structure in the brain with the Globoidcellleukodystrophy disease.
Mouse molecularly-genetical research on the system control of higher brain function on the model of basal nuclei.
Construction of artificial splicing control system of the dystrophin gene with the aim of treatment of the muscular dystrophy.
Genetic mechanism which decides the three-dimensional configuration of the visceral organ.
Decoding of the genome information which regulates cell nucleus.
Functional analysis of Ror2 in formation process of analysis of the chondroosteodystrophy mouse ( the Ror2 acceptor tyrosine kinase transgenic mouse ) and and osteology organization by the biochemical and molecularly-biological technique.
Molecular pathology research on origin mechanism of the neurofibril change.
Research of the genetic background of the joint destruction disease. Analysis which made the aglycan transgenic mouse to be a model system.
Development and application of apoptosis control method based on ASK1 molecule control mechanism.
Analysis of the nerve cell character acquisition mechanism according to the secretion signal.
Elucidation of the role of the prostanoid in the circulatory system using the receptor defect mouse.
Chemoreception of the amine inclusion cell. Elucidation of the emission linkage mechanism.
Elucidation of molecular structure basis of the extacellular calcium perception function of the metabolism type glutamate receptor.
Cholesterol metabolic control protein.
Elucidation of the role of FGF-10 in the fat tissue formation.
Functional analysis of the myosin filament stabilization factor.
Research of amyloid precursor protein and .BETA. protein.
Common molecular mechanism of blood corpuscle and blood vessel generation.
Function in .BETA. amyloid generation of the Alzheimer disease presenilin complex and elucidation of the adjustment mechanism.
Molecular basis of the biophylaxis by the ABC transformer redcap which is related to the foreign body discharge.
Analysis of the protein selection transport mechanism of which nervous system and epithelial cell using the gene deletion mouse are peculiar.
Analysis of protein kinase C targetting mechanism by the live imaging in the nerve cell.
New control mechanism of intercellular adhesion.
Multipotency and chromatin control of the embryonic stem cell.
Role in natural immunity of Toll-likereceptorfamily and the signal transduction.
Molecular basis of foreign body recognition of natural immunity.
Research of genome operating system regulation mechanism of the immunocompetent cell.
Integrin adhesion control by Rap1.
Functional analysis of human Th1 cytospecific transcription factor Txk and expression in autoimmune disease variously.
Survival strategy of the Escherichia coli O157 strain.
Angiogenesis, invasion, metastases to the transition and inhibiting of the thymidine phosphorylase.
Drug discovery science of the angiogenesis depressant which is indispensable to establishment of the new cancer therapy system based on the control of the angiogenesis.
Molecular mechanism of the carcinogenesis by the cell cycle checkpoint abnormality.
Identification of cause gene of the new inheritance renal cancer rat.
Control mechanism of p53 intracellular content.
Molecular-biological research on arachidonic acid metabolism and cell proliferation and canceration.
Control of expression of the human new de-ubiquitination enzyme.
Peroxisome biosynthesis mechanism and the failure.
Generation program of cerebral nerve.
Ubiquitination of the cytokine signal transduction molecule through SOCS-box and elucidation of the physiological significance.
Functional analysis of Syk in the non-blood immune system cell.
Signal transduction route of IL-4 production.
Cloning of the acceptor of sense of pain control peptide nosistatin and elucidation of the production structure.
ATP receptor function elucidation which is related to the pain transmission.
New molecule who is related to a GABA receptor function.
What is histamine's mode of action in mastocyte? Investigation with mouse of histamine absence.
Role of orexin on control of sleep and arousal. The control mechanism of athrocytosis action and alert wakefulness by orexin producing nerve.
Analysis of function control of mast cell mechanism by heparin quantity.
We investigated to define a production of lysophosphatidic acid and mode of the action, and the interaction with disease.
Activation of myosin with action of non-phosphorylation.
Synaptic vesicles renaturation process and phospholipid metabolism.
Identification of iso-aspartic acid denatured protein which accumulates in the degeneration brain.
Research on the abnormality of the information transfer between smooth muscle cell as an origin of the unstable bladder.
Function of the intracellular calcium in transfer and axon induction of the nerve cell.
Modification of the protein membrane permeation equipment to the function rise type.
Analysis of barrier function using the brain barrier Invitro model system.
Action and molecularly-pharmacological research on the role of glia type brain glutamic acid transporter in formation and withdrawal symptom expression which the narcotic drug depends.
Imaging of the hippocampus LTP.
Cerebral cortex controller introduction of the walking movement using the monkey straight bipedal locomotion model. Analysis of the first motor area pyramidal tract cell activity mode using the multi- unit recording method.
Role in a T lymphocyte of the dephosphorization enzyme.
Antigen recognition of natural killer cell and elucidation of the activation mechanism.
Research on the disturbance of self nonself recognition by the chemical substance. For mechanism elucidation and treatment of the chemical substance allergy crisis.
Development of the new herpes simplex virus vector.
Research of breeding mechanism of the human myeloma cell.
Proof of NO fulfiled for the canceration of the human large intestine adenoid tumor cell.
Elucidation of decomposition control mechanism of oncogene Myc.
Intracellular elucidation of tumor supressor gene product PTEN of the active control mechanism.
Application of the control mechanism of new Ced4/Apaf1 like molecule CARD4/Nod1 according to the Ras dependent signal which is related to the execution of the apoptosis to analysis and cancer therapy.
Capacitive Ca2+ inflow and cell cycle.
Development of genome medical treatment for the cardiovascular illness which is based on the genetic disease sensitivity.
Disease state elucidation of the cardiomyopathy by the cytoskeleton protein gene deletion and new development of gene and pharmacotherapy.
Identification of the Crohn disease sensitivity gene.
Research on the gene therapy of inheritance neurologic disease. Research using the Krabbe disease mouse.
Research on cause gene and fit expression process of the epilepsy. Frontal lobe epilepsy the night of the autosome dominance.
Analysis of the peroxylipid in the Alzheimer diseased brain.
Psychosomatic aging and somatotropin downstream relation gene.
Development of the blood vessel, application and regeneration heart valve useing self cell and absorbent polymer by the tissue engineering.
Hybrid artificial bone.
Development of new immunity gene treatment for the hematopoietic tumor.
Development of the new cancer therapy which makes the apoptosis relation molecule to be a target.
Comprehensive research on the establishment of the treatment system for bone metastasis of the cancer.
Establishment of the leukemia model mouse by the FLT3 tyrosine kinase gene introduction.
Identification of the target gene for gene therapy and development for the intractable cancer.
Gene polymorphism and carcinogenesis.Especially, research on gastric cancer crisis risk from the viewpoint of the polymorphism of cytokine relation gene and DNA repair gene in the Helicobacterpylori infection.
Development of operation simulation system which reflects the experience in the doctor maximally. Three-dimensional simulation of cheiloschisis operation which reflects the experience in the doctor.
Diagnosis and prevention of the thrombosis by the gene abnormality.
Research on coronary sclerosis inhibitory effect of inhibitor of angiotensin converting enzyme and angiotensin II receptor antagonist in the rat heterotopia heart transplantation model.
Elucidation of essential hypertension sensitivity gene by the heredity epidemiology.
Cardiac function disorder improvement by the glyrin administration and clinical evaluation of the energy metabolism modification effect.
Quantitative and spatial relation between new birth intimal proliferation in the stent and arteriosclerosis. Studyn using the ultrasonic wave in the intravenous.
Research on the crosstalk of the intracellular communication mechanism by .ALPHA.1 receptor stimulation in the mouse ventricular muscle cell and extension stimulation.
Elucidation of the molecularly-biological mechanism of myocardial infarction early morning crisis.
Production of Leptin in the liver and the pathophysiologic significance. Inflammation and role as a fibrillation controlling element.
Relation of Apo E gene polymorphism and brain grape sugar metabolism and recognition function. PET research of the Alzheimer diseased brain.
Environment hormone, attention defect and hyperkinesia failure which noticed the neuro steroid, cause elucidation of the learning disorder child. Polymorphism of the peripheral type benzodiazepine.
Identification of new cause gene of girdle type muscular dystrophy and functional analysis of the protein.
Establishment of the disease concept of "aberrant diabetes mellitus (NIDDM1) of calpain 10" and elucidation of mechanism of pathogenesis.
Hypertension and hypertension organ derangement and role of the kallikrein-kinin system. The relation with the gene point mutation.
Analgesic action mechanism elucidation of steroidal system anesthetic alfaxalone and morphine derivative tramadol. Analgesic development by the analysis method using culture adrenomedullary cell and chimera G protein acceptor.
Development of the self regenerative artificial structure by the identification of the differentiation function regulation gene cluster.
Development of the growth factor inclusion artificial cell outside matrix according to the molecular design and regeneration of the bone using the private use fibroblast.
Research on heteroantigen reactivity T cell by introduction of the different hemopoietic stroma chimerism and induction of B cell tolerance. Establishment of rejection control method with the aim of the clinical introduction of the heterogenous organ trans-plantation.
Low responsiveness for .ALPHA.-galactosylceramide of the cancer patient derivation V.ALPHA.24NKT cell.
Action mechanism in the air duct cell of Transforming growthfactor-.BETA..
Role in helper T cell differentiation of a CD25 positive CD4 positive immunoregulation T cell.
Examination of immune response in osteoarthrosis.
Research on elucidation of involvement of hepatic sinusoid parietal cell which controls hepatocyte immunity for the generation and progress of hepatoma and the clinical application.
Mismatch repair abnormality and anticancer agent sensitivity.
Oncogene treatment by proliferation control type ADV development.
Development of anti-caries restorative dental materials for the elderly.
Study on the cardiac hypertrophy by angiotensin II. Mechanism through the AT2 receptor.