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List of Jounal Titles
A to Z index of Journal Title. Choose a letter.
Xenobiotic Metabolism and Disposition
14
- Design of drugs involving the concept and theories of drug metabolism and pharmacokinetics.
- Clinical impact of pharmacogenomics.
- Pharmacogenomics and drug discovery.
- The toxicity and detoxification of .ALPHA.,.BETA.-unsaturated aldehydes.
- Roles of human P450 enzymes in drug oxidations using recombinant P450S and human liver microsomes.
- Variations in contents of liver microsomal cytochrome P450 isoforms and activities of drug oxidations in humans.
- Characterization of oxidation of optically active substrates by rat and human CYP2D enzymes expressed insaccharomyces cerevisiae.
- Factors involved in the induction of the CYP2B subfamily P450: Search for the target of inducers using photoaffinity probe and the role of sterols in the induction.
- Detection of human drug metabolizing enzyme induction in vivo: development of method for measurement of P450 mRNA levels in peripheral lymphocyte by quantitative PCR.
- Species difference in drug metabolizing activity in small intestine.
- Transcriptional regulation of CYP3A subfamily.
- The property of expressed CYP2D6*10 and its possibility as a tool for predicting human pharmacokinetics.
- Prediction of the in vivo drug metabolizing activity in human liver from in vitro data on metabolism: The use of human liver microsomes and recombinant human CYP isozymes.
- Analysis of genetic polymorphism on the promoter region of a human liver carboxylesterase gene.
- Catalytic properties of polymorphic human tissue phenol sulfotransferases.
- Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity.
- The study on CYP2A6 genetic polymorphism.
- Transport mechanism of organic anion drug across the blood-placental barrier.
- Transport Characteristics and Substrate Specificity in Rat Inner Blood-Retinal Barrier Cell Line(TR-iBRB).
- Uptake and efflux transport mechanisms of tolbutamide across the blood-brain barrier.
- The role of MRP family proteins in detoxification of xenobiotics in liver and intestine.
- Identification and characterization of human liver-specific organic anion transporter LST-1.
- Multiolicity of functional characterization and tissue distribution of OCTN-transporter family.
- Liver Cell-Selective Targeting Using Glycosylated Liposomes.
- Pharmacokinetic studies of theophylline and valproic acid in plasma, cerebrospinal fluid and tear: assesment of tear concentrations on tdm.
- Intestinal absorption of an ester-type prodrug ME3229. Studies on the efflux of metabolites formed in the enterocytes into the gut lumen.
- Prediction of oral absorption of cephalosporins in humans: Studies with rat intestinal brush border membrane vesicles and caco-2 cells.
- Assessment of bioavailability from pharmacological responses.
- Prediction of the effectiveness of charcoal hemoperfusion treatment in drug overdose: a guideline based on the protein binding percentage and distribution volume of the drug.
- Chimpanzee Cytochromes P450(CYPs) and "Phase Zero" Study.
- Real-time analysis by microdialysis-tandem mass spectrometry(MD-MS/MS).
- Pharmacokinetic analysis of disposition of vanadyl complexes as insulin-mimetics in rats using BCM-ESR and NAA methods.
1
- Absorption, Distribution and Excretion of 14C-labeled Tacrolimus(FK506) Ointment after a Single Dermal Application to the Rat.
- Pharmacokinetics of Tacrolimus(FK506) Ointment after a Single Dermal Application to the Rat.
- Effect of 2-Methylimidazole on the Mechanical, Biochemical, and Morphological Properties of the Rat Aorta by Its Chronic Treatment along Maturation.
- WinPBPK-A Software for Physiologically-based Pharmacokinetic Model Analysis: Application to Tissue and Organ Distribution Analysis of Tacrolimus.
- Ocular Tissue Distribution in Rabbit after Instillation of Bromfenac Sodium Ophthalmic Solution.
- Radioluminography(RLG) in the Drug Evaluation Studies: Validation, Microplate-RLG and a Quantitative Whole Body Autoradiography.
2
- Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (4). Interspecies Variation in Laboratory Animals and Humans.
- Metabolic Fate of Azasetron Hydrochloride. (III). Absorption, Distribution, Metabolism and Excretion of 14C-Azasetron Hydrochloride after Oral Administration to Rats.
- Metabolic Fate of Azasetron Hydrochloride. (IV). In Vitro Metabolism of Azasetron Hydrochloride by Rat and Dog Liver Microsomes.
- Novel Drug Metabolizing Enzymes Identified from Cannabinoid Metabolic Studies, and Their Reaction Mechanisms.
- Quantitative Evaluation of Factors Affecting Drug Distribution in Body.
- Exploring the Way of Pharmacokinetics-based Evaluation of Drug Efficacy and Safety.
- Biological Functions of Cytochrome P450s in the CYP4 Family.
- Investigation of Mechanisms Underlying the Pharmacokinetics of Peptide Drugs and their Physiological Model Analysis.
- Molecular Mechanisms of Intestinal Absorptive and Secretory Transports of Drugs.
- Intestinal Absorption Mechanisms of .BETA.-Lactam Antibiotics.
3
- Studies on the Metabolic Fate of Flecainide Acetate. (1). Blood Levels, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration.
- Studies on the Metabolic Fate of Flecainide Acetate. (2). Blood Levels, Distribution, Metabolism and Excretion in Dogs after a Single Intravenous Administration.
- Outlines of New Guidances and from the Viewpoint of Clinical Trial Guidances.
- Pharmacokinetic Studies to Support Clinical Trials: From Scientific Perspective.
- From the View Point of Drug Development.
- Screening Phase I and FDA-Type Single Dose Toxicity Studies.
- Human In Vitro Study.
- Opinion from Clinician.
- Is delivery promotion in the nucleus of the gene by the nuclear localization signal possible ?
- The new development of the mechanism of CYP2B induction.
- The possibility of liver slice utilization in the medical supply development.
4
- Oxidative Metabolism of Tacrolimus and its Metabolite by Human Cytochrome P450 3A Subfamily.
- Moment Analysis Program available on Microsoft Excel.
- Pharmacokinetic Study of a Cepharosporin Derivative in Infant and Adult Dogs.
- Studies on the Metabolic Fate of Pramipexole (SND 919 CL2Y). (I). Absorption, Distribution and Excretion after a Single Oral Administration to Rats.
- Studies on the Metabolic Fate of Pramipexole (SND 919 CL2Y). (II). Absorption and Distribution after Repeated Oral Administration to Rats.
- Improvement of Transmucosal Absorption of Peptide and Protein Drugs.
- The uninvasive measurement of the center local field acetylcholinesterase activity.
- AIDS drug and P - glycoprotein.
- The generation of 2' - deoxynucleoside by the 4 - hydroxyequilenin and adduct with DNA.
5
- Validation Studies of Radioluminography. II. A Method for Monitoring Radioactive Contamination of Imaging Plates.
- Metabolic Fate of YM992. Absorption, Distribution, Excretion and Metabolic Fingerprinting after a Single Oral Administration of 14C-YM992 to Rats.
- Penetration and Absorption of Tacrolimus (FK506) Ointment in the Skin After a Single Dermal Application to the Rat.
- Emulsion Type New Vehicle for Soft Gelatin Capsule Available for Preclinical and Clinical Trials. Stabilization of New Vehicle Containing Vitamin K2 with PEG 6000.
- An Active Morphine Glucuronide Responsible for Morphine Analgesia.
6
- Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (5). In Vitro Metabolism and Plasma Protein Binding in Animals and Human.
- Pharmacokinetics of 14C-Telmisartan. (1). Absorption, Distribution and Protein Binding of 14C-Telmisartan after a Single Oral Administration to Rats.
- Pharmacokinetics of 14C-Telmisartan. (2). Plasma Concentration and Distribution of 14C-Telmisartan after Repeated Oral Administration to Rats.
Supplement
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