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List of Jounal Titles
A to Z index of Journal Title. Choose a letter.
Xenobiotic Metabolism and Disposition
16
- Drug induction of P450 genes: History, mechanism, and implication.
- MEchanism for Production of Pharmacologically Active Metabolite of CS-747, A New Anti-Platelet Agent.
- Finding of a novel receptor for uridines using two enantiomer metabolites of a new hypnotic, N3-Phenacyluridine, Its action mechanism and application to development of drug.
- The role of novel cytochrome P450S in the metabolism of an antihistamine ebastine in human intestine.
- Pharmacokinetics of capecitabine, of triple-prodrug of 5-FU: Usefulness of physiologically based pharmacokinetic model for quantitative understanding of tumor-selective distribution of 5-FU after oral administration of the triple-prodrug.
- Drug Metabolism Studies in Discovery Stage using human materials.
- Significance of human in vitro studies and its perspective.
- Enzyme induction: Its assessment in human hepatocytes and its impact on the drug approval process.
- Multiplicity of carboxylesterase isozymes in mammals and humans: Role in metabolic activation of prodrugs.
- Interaction of cytochrome P450 and microsomal epoxide hydrolase and UDP-glucuronosyltransferase.
- Evaluation of the monkey as a model of human in drug metabolism study: Focusing CYP2D enzymes.
- Urinary 6.BETA.-hydroxycortisol/cortisol ratio does not reflect in vivo CYP3A activity in humans.
- Drug Metabolism: Predictive and Database Tools.
- New Aspects of Drug Transporter Research: From Bench to Bedside.
- Importance of evaluating contributions of transporters in drug development An approach using selective inhibitors.
- Contributions of Transporter on Pharmacokinetics of New Drug Candidates.
- Functional analysis of the blood brain barrier using conditionally immortalized cell lines.
- Characterization of drug transport mechanism across the placental barrier using cultured trophoblast.
- Tissue distribution and functional characterization of organic cation/carnitine transporter OCTN1.
- Evaluation of drug targeting ability to the local organ site by a new administration utilizing absorption from organ surface.
- Effects of oxidation on functional systems of human serum albumin.
- Differential expression of transporters in the intestine and its application to regulation of the drug absorption.
- Elucidation of mechanisms behind cytoprotective effects of amino acids: Improvement of mucosal injury caused by absorption enhancer.
- Standardization of in vitro drug permeability in Caco-2 study and their correlation to human data in vivo.
- DDS technology required for effective in vivo gene transfer.
- Application of DDS for the gene therapy.
- Discovery of functional genes by novel RNA-protein hybrid ribozyme libraries in the post genome era.
- A metabolism-based approach to elucidating the mechanism of liver dysfunction induced by troglitazone. Is the liver dysfunction in patients treated with troglitazone related to polymorphism of UGTs?
- Research on Pharmacokinetics related Genetic Polymorphism among Japanese Population(Pharma SNP Consortium: PCS).
- Genotyping of Drug Metabolizing Enzymes, Drug Transporters, and Drug Receptors for Individualization of Drug Therapy.
- Phaemacokinetic/pharmacodynamic modeling in clinical pharmacological studies.
- Membrane-permeability assay using Caco-2 cells in drug discovery.
- Development of drug metabolism study in drug discovery.
- Screening of physical properties in pharmaceutical discovery.
- Can in silico screening systems provide us with the tools to predict the DMPK properties of drugs in the discovery process?
- Studies on metabolic fate of pitavastatin(NK-104), a new inhibitor of HMG-CoA reductase-Does glucronidation mediate the lactonization of pitavastatin?
- Interaction of dexloxiglumide(CR2017) with human cytochromes P450.
- QSPR analysis on inhibition of recombinant CYP3A4 activity by structurally diverse compounds using genetic algorithm combined partial least squares method.
- Studies on metabolic fate of pitavastatin(NK-104), a new inhibitor of HMG-CoA reductase-Is the metabolism of pitavastatin in monkey similar to that in human?
- A comprehensive investigation of cryopreserved human hepatocytes.
- A convenient non-hplc marker assay for measuring CYP2C8 activity in human liver microsomes: 5- and 6-chloromethylfluorescein diethyl ether(CMFDee) O-dealkylation.
- Drug interactions of indinavir to other HIV protease inhibitors: Contribution of hepatic and intestinal metabolism.
1
- Electrophysiological Evaluation for Conditions of Preservation of Isolated Human Colon Tissues.
- Interaction of Azole Antifungal Agents with Human P-glycoprotein Expressed in a Kidney Epithelial Cell Line, LLC-PK1.
- The Mechanism for the Induction of Cytochrome P450 2B Subfamily: Progress of Research and Future Problem.
- Transcriptional Regulation of the CYP2C12 Gene in Female Rats.
- Role of Denitration in Pharmacokinetics and Pharmacodynamics of Organic Nitrates.
- Development and Application of the Strategy for the Quantitative Prediction of Drug-induced Parkinsomisms.
- Receptor-mediated Endocytosis in Renal Tubules and its Dysfunction Induced by Drugs.
2
- Frequency Distribution of CYP2C19, CYP2D6, and CYP2C9 Mutant-alleles in Several Different Populations.
- Clinical Application of Pharmacokinetics/Pharmacodynamics. From Animal to Human, and Normal to Disease.
- Development of Evaluation Methods and Computer Softwares for Pharmacokinetic Analysis.
- Novel Metabolic Pathways of Cysteine Conjugate and its Related Metabolites.
- In Vitro Evaluation of Drug Interaction Caused by Enzyme Inhibition. HAB Protocol.
- Genetic Polymorphism of Drug Transporters.
- Role of Renal Organic Anion Transporters, OAT-K1 aud OAT-K2, in the Urinary Excretion of Anionic Drugs.
- Transport Mechanism of Basic Fibroblast Growth Factor through the Blood-Brain Barrier.
- Study of Metabolism and Cytotoxicity of Troglitazone.
- Acetaminophen Hepatotoxicity and Cytokines.
3
- Concentration of the Sulfur-containing Metabolites of m-Dichlorobenzene in Rats Bile and Urine.
- Japanese Guidance on Clinical Pharmacokinetic Studies and Review of the New Drug Applications.
- Industrial Views on the Draft Guidance for Clinical Pharmacokinetic Study.
- Japanese Guidance on Drug Interaction Studies. Introduction of the Guidance and its Comparison with those of EU and US.
- Guidance on Drug Interaction Studies. From the Standpoint of Clinical Field aud Science.
- Guidance on Drug Interaction Studies: From the Aspect of Drug Development.
- Guidance on Drug Interaction Studies: From the View Point of the Post Marketing.
- Statistical Assessment of Linear Pharmacokinetics in Clinical Pharmacological Studies.
- Method of AUC Estimation from Sparse Sampling Data.
- Role of Transporter and Metabolic Enzyme in Sequential and Competitive Process of Intestinal Absorption: Study on SGLT1, Disaccharidase and Peptidases.
- A Topological Analysis of the Drug Binding Sites on Human Serum Albumin.
4
- Studies on the Disposition of TSH-01, a New Transdermal System of Estradiol: Absorption and Plasma Concentration in Rats after a Single Transdermal Application.
- Studies on the Metabolic Fate of M17055, a Novel Diuretic. (1): Plasma Concentration and Excretion of Radioactivity in Rat and Dog after a Single Intravenous Administration of [14C]M17055.
- Studies on the Metabolic Fate of M17055, a Novel Diuretic. (2): Tissue Distribution and Transfer of Radioactivity into Fetus and Milk in Rat after a Single Intravenous Administration of [14C]M17055.
- Studies on the Metabolic Fate of M17055, a Novel Diuretic. (3): Plasma Concentration, Distribution and Excretion of Radioactivity in Male Rats after Repeated Daily Intravenous Administration of [14C]M17055.
- Functional Genomics and Pharmacology for Drug Development.
- Pharma SNP Consortium (PSC). Research on Pharmacokinetics related Genetic Polymorphism among Japanese Population.
- Pharmacogenomics: Genetic Polymorphism of Receptors and Variation in Drug Response.
- Pharmacogenomics in Drug Discovery and Development Research.
- How Foreign Clinical Data Package can be Utilized to get a Speedy Approval of the New Drug. The Bridging Study Strategy.
5
- Metabolic Fate of Esmolol.
- Stereoselective Pharmacokinetecs of Esmolol Enantiomers.
- Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu13]motilin-Hse). (I): Distribution and Accumulation in Rats after Single or Repeated Intravenous Injection of 3H-SK-896.
- Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu13]motilin-Hse). (II): Blood and Plasma Concentration and Excretion in Rats afrter Single Intravenous Injection or Constant Rate Intravenous Infusion of 3H-SK-896.
- Development of a Sustained Release Preparation of Diclofenac Sodium and its Pharmacokinetics in Dogs.
- Polymorphism of Cytochrome P450 Genes and Drug Disposition.
- Strategic Approach for Drug Metabolism and Pharmacokinetic Research in the Drug Discovery Process.
- Bioethics in Genomics.
- Molecular Mechanism of Human CYP3A4 Induction.
6
- Effect of Biliary Excretion on the Pharmacokinetics of Pitavastatin (NK-104) in Dogs.
- Pharmacokinetic Studies of [14C]Urea. (1); Absorption, Distribution, Metabolism and Excretion after Single Administration of [14C]Urea in Fasted Rats.
- Pharmacokinetic Studies of [14C]Urea. (2); Absorption, Distribution, Metabolism and Excretion after Administration of [14C]Urea in Non-Fasted Rats.
- Pharmacokinetic Studies of [14C]Urea. (3); Feto-placental Transfer and Excretion into Milk after Single Oral Administration of [14C] Urea in Rats.
- Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu13]motilin-Hse). (III): Feto-Placental Transfer and Excretion into Milk in Rats after Single Intravenous Injection of 3H-SK-896.
- Pharmacokinetics of SNI-2011. (1): Absorption, Distribution, Metabolism and Excretion of 14C-SNI-2011 in Rats.
- Pharmacokinetics of SNI-2011. (2): Absorption, Excretion and Metabolism of 14C-SNI-2011 in Dogs.
- Metabolism of Quazepam and its Metabolites in Humans: Identification of Metabolic Enzymes and Evaluation of Drug Interaction In Vitro.
- Pharmacokinetics of Buprenorphine Hydrochloride (BN HCl). (1). Absorption, Distribution, Metabolism and Excretion after Percutaneous (TSN-09: BN HCl Containing Tape Application) or Subcutaneous Administration of BN HCl in Rats.
- Pharmacokinetics of Buprenorphine Hydrochloride (BN HCl). (2): Role of Stratum Corneum in Percutaneous Absorption of TSN-09 (BN HCl containing tape) in Male Rats.
Supplement
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